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Titolo:
HUMAN INTESTINAL INTRAEPITHELIAL LYMPHOCYTES ARE DERIVED FROM A LIMITED NUMBER OF T-CELL CLONES THAT UTILIZE MULTIPLE V-BETA T-CELL RECEPTOR GENES
Autore:
BLUMBERG RS; YOCKEY CE; GROSS GG; EBERT EC; BALK SP;
Indirizzi:
HARVARD UNIV,BETH ISRAEL HOSP,SCH MED,DIV HEMATOL ONCOL,330 BROOKLINEAVE BOSTON MA 02215 HARVARD UNIV,BETH ISRAEL HOSP,SCH MED,DIV HEMATOL ONCOL,330 BROOKLINEAVE BOSTON MA 02215 HARVARD UNIV,BRIGHAM & WOMENS HOSP,SCH MED,DIV GASTROENTEROL BOSTON MA 02115 UNIV MED & DENT NEW JERSEY,DIV GASTROENTEROL NEW BRUNSWICK NJ 08903
Titolo Testata:
The Journal of immunology
fascicolo: 11, volume: 150, anno: 1993,
pagine: 5144 - 5153
SICI:
0022-1767(1993)150:11<5144:HIILAD>2.0.ZU;2-9
Fonte:
ISI
Lingua:
ENG
Soggetto:
CD8 ACCESSORY MOLECULE; GAMMA-DELTA; GUT EPITHELIUM; ALPHA-BETA; ANTIGEN RECEPTOR; EXPRESSION; DIFFERENTIATION; RECOGNITION; USAGE; MICE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
41
Recensione:
Indirizzi per estratti:
Citazione:
R.S. Blumberg et al., "HUMAN INTESTINAL INTRAEPITHELIAL LYMPHOCYTES ARE DERIVED FROM A LIMITED NUMBER OF T-CELL CLONES THAT UTILIZE MULTIPLE V-BETA T-CELL RECEPTOR GENES", The Journal of immunology, 150(11), 1993, pp. 5144-5153

Abstract

Intestinal intraepithelial lymphocytes (IEL) are a phenotypically distinct T cell population of unknown function. The majority of human intestinal IEL express the TCR-alphabeta, the CD8 accessory molecule, andthe CD45RO Ag, suggesting that they are MHC class I-restricted memoryT cells. Recent analyses of the TCR alpha- and beta-chains expressed by these cells have shown marked skewing toward one or several V region genes in individual donors and revealed the presence of clonally expanded cells. In addition, functional data has suggested that the MHC class I-like CD1 molecules may be the target ligands for some human intestinal IEL clones. This report examines in detail the TCR-beta repertoire of human jejunal IEL to determine what fraction of these cells are clonally expanded and to determine whether a particular subset of Vbeta genes are utilized by the clonally expanded cells. The results demonstrate that the majority of IEL are derived from the expansion of a relatively few T cell clones and that these clones can utilize a largenumber of different Vbeta genes. Oligoclonal expansion is also demonstrated among lamina propria lymphocytes (LPL), with overlapping but distinct clones detected in the LPL vs the IEL populations. These results indicate that most intestinal IEL-alphabeta, and a subpopulation of LPL, are specific for a limited number of Ag and place constraints on the possible roles played by IEL in the defense against diverse environmental pathogens or in the generation of oral tolerance.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 20/09/20 alle ore 04:58:39