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Titolo:
TISSUE AND UROKINASE PLASMINOGEN ACTIVATORS IN THE ENVIRONS OF VENOUSAND ISCHEMIC LEG ULCERS
Autore:
STACEY MC; BURNAND KG; MAHMOUDALEXANDRONI M; GAFFNEY PJ; BHOGAL BS;
Indirizzi:
UNIV WESTERN AUSTRALIA,FREMANTLE HOSP,DEPT SURG,POB 480 FREMANTLE WA AUSTRALIA ST JOHNS HOSP DIS SKIN LONDON WC2H 7BJ ENGLAND ST THOMAS HOSP,DEPT SURG LONDON SE1 7EH ENGLAND NATL INST BIOL STAND & CONTROLS LONDON NW3 6RB ENGLAND
Titolo Testata:
British Journal of Surgery
fascicolo: 5, volume: 80, anno: 1993,
pagine: 596 - 599
SICI:
0007-1323(1993)80:5<596:TAUPAI>2.0.ZU;2-L
Fonte:
ISI
Lingua:
ENG
Soggetto:
BASEMENT-MEMBRANE COLLAGEN; EPIDERMAL-CELL MIGRATION; WOUND REEPITHELIALIZATION; FIBRINOLYTIC-ACTIVITY; ZONE ANTIGENS; FIBRONECTIN; DEGRADATION; ULCERATION; FIBRINOGEN; INHIBITORS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
29
Recensione:
Indirizzi per estratti:
Citazione:
M.C. Stacey et al., "TISSUE AND UROKINASE PLASMINOGEN ACTIVATORS IN THE ENVIRONS OF VENOUSAND ISCHEMIC LEG ULCERS", British Journal of Surgery, 80(5), 1993, pp. 596-599

Abstract

Urokinase plasminogen activator (uPA) and tissue plasminogen activator (tPA) were assayed in biopsies from the base, edge and adjacent skinof ischaemic and venous ulcers using a functional bioimmunoassay and a standard immunoassay. Two series of 14 biopsies were examined: from seven venous and seven ischaemic ulcers in the first series, eight venous and six ischaemic in the second. It was found that tPA was detected in only four samples of ulcer edge using the bioimmunoassay and in no sample by the standard immunoassay. By contrast, uPA was detected inall but one ulcer edge biopsy and at a significantly lower me&an concentration in the adjacent skin (16.9 units/g) than the ulcer edge (26.1 units/g) or base (32.3 units/g) (both P < 0.01). Levels of uPA were greater in the edge and base of venous compared with ischaemic ulcers. The predominant plasminogen activator in chronic leg ulcers is uPA; this activator may play an important role in wound healing.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 12/07/20 alle ore 06:41:04