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Titolo:
SELECTING HUMAN CHORIONIC-GONADOTROPIN IMMUNOASSAYS - CONSIDERATION OF CROSS-REACTING MOLECULES IN 1ST-TRIMESTER PREGNANCY SERUM AND URINE
Autore:
COLE LA; SEIFER DB; KARDANA A; BRAUNSTEIN GD;
Indirizzi:
YALE UNIV,SCH MED,DEPT OBSTET & GYNECOL,308 FMB,333 CEDAR ST NEW HAVEN CT 06510 UNIV CALIF LOS ANGELES,CEDARS SINAI MED CTR,DEPT MED LOS ANGELES CA 90048
Titolo Testata:
American journal of obstetrics and gynecology
fascicolo: 5, volume: 168, anno: 1993,
pagine: 1580 - 1586
SICI:
0002-9378(1993)168:5<1580:SHCI-C>2.0.ZU;2-N
Fonte:
ISI
Lingua:
ENG
Soggetto:
BETA-SUBUNIT; MONOCLONAL-ANTIBODIES; HCG;
Keywords:
HUMAN CHORIONIC GONADOTROPIN; PREGNANCY; IMMUNOASSAY;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
19
Recensione:
Indirizzi per estratti:
Citazione:
L.A. Cole et al., "SELECTING HUMAN CHORIONIC-GONADOTROPIN IMMUNOASSAYS - CONSIDERATION OF CROSS-REACTING MOLECULES IN 1ST-TRIMESTER PREGNANCY SERUM AND URINE", American journal of obstetrics and gynecology, 168(5), 1993, pp. 1580-1586

Abstract

OBJECTIVE: We investigated the variation in human chorionic gonadotropin results found with different commercial kits. Levels of human chorionic gonadotropin and related molecules were determined in pregnancy serum and urine and compared with the specificities of different laboratory, office, and home test kits. STUDY DESIGN: Total human chorionicgonadotropin (nicked + nonnicked), nonnicked human chorionic gonadotropin, free beta subunit, and beta core fragment were measured in 242 serum samples and 125 urine samples from early pregnancies. RESULTS: Inserum, in the 2 weeks after the missed period when most pregnancy tests are performed, median levels of total, nonnicked, and beta human chorionic gonadotropin (total + free beta + beta core) were similar (less-than-or-equal-to 12% difference). Individual values, however, variedsignificantly. For nonnicked human chorionic gonadotropin, values ranged from 41% to 145% and for beta from 101% to 145% of the total humanchorionic gonadotropin level. In urine individual nonnicked values varied from < 1% to 148% and beta values from 102% to 547% of the total human chorionic gonadotropin level. A survey of 29 kits revealed that 10 were types detecting total human chorionic gonadotropin, five detecting nonnicked only, and 14 were beta assays. CONCLUSIONS: Results from total, nonnicked, and beta human chorionic gonadotropin kits are notnecessarily interconvertible. Individual variations in levels of nicked human chorionic gonadotropin, free and beta core, and differences in their recognition by immunoassays causes discordant results.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/11/20 alle ore 17:37:28