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Titolo:
EFFICIENCY OF HEMODIALYSIS OF PYRIMIDINE COMPOUNDS IN PATIENTS WITH CHRONIC-RENAL-FAILURE
Autore:
DANIEWSKAMICHALSKA D; MOTYL T; GELLERT R; KUKULSKA W; PODGURNIAK M; OPECHOWSKAPACOCHA E; OSTROWSKI K;
Indirizzi:
CENT CLIN HOSP,WARSAW MED SCH,DEPT MED,BLOCK D,BANACHA 1A PL-02097 WARSAW POLAND AGR UNIV WARSAW,FAC VET MED,DEPT ANIM PHYSIOL PL-02528 WARSAW POLAND
Titolo Testata:
Nephron
fascicolo: 2, volume: 64, anno: 1993,
pagine: 193 - 197
SICI:
0028-2766(1993)64:2<193:EOHOPC>2.0.ZU;2-Z
Fonte:
ISI
Lingua:
ENG
Soggetto:
AMBULATORY PERITONEAL-DIALYSIS; URINARY-EXCRETION; PSEUDOURIDINE; FLUIDS; SERUM;
Keywords:
PYRIMIDINES; HEMODIALYSIS; CHRONIC RENAL FAILURE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
19
Recensione:
Indirizzi per estratti:
Citazione:
D. Daniewskamichalska et al., "EFFICIENCY OF HEMODIALYSIS OF PYRIMIDINE COMPOUNDS IN PATIENTS WITH CHRONIC-RENAL-FAILURE", Nephron, 64(2), 1993, pp. 193-197

Abstract

The accumulation in blood plasma and efficiency of hemodialysis of-pyrimidine compounds (orotic acid, orotidine, pseudouridine, uridine, thymine) as well as uric acid and creatinine in 23 patients with chronicrenal failure (CRF) was investigated. As a reference, the analysis ofthe above metabolites in the plasma of 30 healthy volunteers was performed. Among examined compounds, pseudouridine possessed the highest capability of accumulation in blood plasma (25 times higher concentration than physiological). It coincided with the lowest efficiency of pseudouridine hemodialysis (44%) and the longest T1/2 (relative to creatinine) in plasma. A significant linear correlation (r= 0.81, p < 0.001)between efficiency of creatinine and pseudouridine hemodialysis was calculated. The concentration of orotic acid in the blood plasma of patients before hemodialysis exceeded 14 times its level in healthy subjects; the inhibition of uric acid synthesis by allopurinol in dialyzed patients was accompanied by enlargement of orotidine and orotate accumulation in blood plasma. Extremely high plasma concentration of examined pyrimidines remaining elevated after hemodialysis creates an additional hazard for tissue metabolism and health of patients with CRF.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/07/20 alle ore 04:12:45