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Titolo:
ORGANIZATION AND PROMOTER ACTIVITY OF THE MOUSE SYNDECAN-1 GENE
Autore:
HINKES MT; GOLDBERGER OA; NEUMANN PE; KOKENYESI R; BERNFIELD M;
Indirizzi:
CHILDRENS HOSP MED CTR,JOINT PROGRAM NEONATOL,ENDERS BLDG,RM 950,300 LONGWOOD AVE BOSTON MA 02115 HARVARD UNIV,SCH MED,DEPT NEUROL BOSTON MA 02115 HARVARD UNIV,SCH MED,JOINT PROGRAM NEONATOL BOSTON MA 02115
Titolo Testata:
The Journal of biological chemistry
fascicolo: 15, volume: 268, anno: 1993,
pagine: 1440 - 1448
SICI:
0021-9258(1993)268:15<1440:OAPAOT>2.0.ZU;2-M
Fonte:
ISI
Lingua:
ENG
Soggetto:
CELL-SURFACE PROTEOGLYCAN; MAMMARY EPITHELIAL-CELLS; FIBROBLAST GROWTH-FACTOR; HEPARAN-SULFATE PROTEOGLYCANS; NF-KAPPA-B; INTEGRAL MEMBRANE PROTEOGLYCAN; MESENCHYMAL INTERACTIONS; EXPRESSION; DIFFERENTIATION; RECEPTOR;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
79
Recensione:
Indirizzi per estratti:
Citazione:
M.T. Hinkes et al., "ORGANIZATION AND PROMOTER ACTIVITY OF THE MOUSE SYNDECAN-1 GENE", The Journal of biological chemistry, 268(15), 1993, pp. 1440-1448

Abstract

Syndecan-1, the prototype of a family of heparan sulfate-containing integral membrane proteoglycans, associates extracellularly with a variety of matrix molecules and growth factors and intracellularly with the actin cytoskeleton. Expressed constitutively on epithelia in mature tissues and in a developmentally regulated manner on epithelial and induced mesenchymal cells during embryogenesis, syndecan-1 appears to beinvolved in controlling the shape and organization of cells and tissues. To better understand the function and regulation of syndecan- 1, we determined the structure of the mouse syndecan-1 gene (Synd-1). Synd-1 is approximately 19.5 kilobases in size and is organized into five exons that appear conserved in other family members. Exon 1 encodes the signal peptide; exon 2, the N-terminal glycosaminoglycan attachment region; exon 3, the bulk of the extracellular domain; exon 4, the protease-susceptible site; and exon 5, the transmembrane and cytoplasmic domains which are highly homologous between syndecan family members. Synd-1 has three transcriptional start sites, two polyadenylation sites,and is not alternatively spliced to produce its 2.6- and 3.4-kilobasemRNA species. Upstream sequences have promoter activity and contain TATA and CAAT boxes as well as a variety of other potential binding sites for transcription factors, including Sp1 (GC box), NF-kappaB, MyoD (E box), and Antennapedia. The structure of the promoter region suggests that control of Synd-1 expression is both constitutive and developmentally regulated. Because Synd-1 exons encode discrete functional domains of the syndecan-1 protein that are conserved throughout the syndecan family, all syndecan genes are likely derived from a common ancestor.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 08/08/20 alle ore 23:26:29