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Titolo:
EVIDENCE FOR INVOLVEMENT OF BRAIN DOPAMINE AND OTHER MECHANISMS IN THE BEHAVIORAL ACTION OF THE N-METHYL-D-ASPARTIC ACID ANTAGONIST MK-801 IN CONTROL AND 6-HYDROXYDOPAMINE-LESIONED RATS
Autore:
CRISWELL HE; JOHNSON KB; MUELLER RA; BREESE GR;
Indirizzi:
UNIV N CAROLINA,SCH MED,BRAIN & DEV RES CTR,CB 7250 CHAPEL HILL NC 27599 UNIV N CAROLINA,SCH MED,DEPT PSYCHIAT CHAPEL HILL NC 27599 UNIV N CAROLINA,SCH MED,DEPT PHARMACOL & ANESTHESIOL CHAPEL HILL NC 27599 UNIV N CAROLINA,SCH MED,CURRICULUM NEUROBIOL CHAPEL HILL NC 27599
Titolo Testata:
The Journal of pharmacology and experimental therapeutics
fascicolo: 2, volume: 265, anno: 1993,
pagine: 1001 - 1010
SICI:
0022-3565(1993)265:2<1001:EFIOBD>2.0.ZU;2-U
Fonte:
ISI
Lingua:
ENG
Soggetto:
NEONATAL 6-OHDA-LESIONED RATS; MONOAMINE-DEPLETED MICE; NMDA RECEPTOR; CATECHOLAMINE NEURONS; TYROSINE-HYDROXYLASE; LOCOMOTOR-ACTIVITY; H-3 DOPAMINE; AMPHETAMINE; RESPONSES; AGONISTS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
51
Recensione:
Indirizzi per estratti:
Citazione:
H.E. Criswell et al., "EVIDENCE FOR INVOLVEMENT OF BRAIN DOPAMINE AND OTHER MECHANISMS IN THE BEHAVIORAL ACTION OF THE N-METHYL-D-ASPARTIC ACID ANTAGONIST MK-801 IN CONTROL AND 6-HYDROXYDOPAMINE-LESIONED RATS", The Journal of pharmacology and experimental therapeutics, 265(2), 1993, pp. 1001-1010

Abstract

Behavioral activation following systemic administration of the N-methyl-D-aspartic acid receptor antagonist MK-801 1-dihydroxy-5H-dibenzo(a,d)cyclohepten-5,10-imine; dizocilpine} was examined in unlesioned control and in neonatal-6-hydroxydopamine (OHDA) lesioned rats. Neonatal-6-OHDA lesioned animals were found more sensitive than control rats and female rats more sensitive than males to this MK-801-induced behavioral activation. CGS-19755, a competitive NMDA antagonist, also increased activity in neonatally lesioned animals. The increased activity level following MK-801 administration to neonatally lesioned rats was reduced, but not eliminated, by pretreatment with a-methyltyrosine, indicating that endogenous catecholamines were partially responsible for this action of MK-801. Furthermore, neither a D1- nor a D2-dopamine antagonist was totally effective alone in reducing MK-801-induced behavioral activation in the neonatally lesioned rats, but MK-801-induced activity was reduced to the level observed after alpha-methyltyrosine whenboth dopamine antagonists were administered in combination. In contrast to these results, alpha-methyl-tyrosine virtually eliminated the MK-801-induced activity in adult-lesioned rats. When individual behaviors induced by MK-801 were examined in neonatal-6-OHDA lesioned rats, MK-801 did not produce the same behaviors as L-dihydroxyphenylalanine ora D1- or D2-dopamine agonist. Whereas MK-801 had no major effect on most behaviors induced by specific D1- or D2-dopamine agonists, it blocked some behaviors produced after L-dihydroxyphenylalanine administration, including the self-injurious behavior. Repeated MK-801 treatment resulted in increasingly greater motor activity, but this was not related to increased D1-dopamine receptor sensitization. In support of a regional action of MK-801, MK-801 induced c-fos-like immunoreactivity in the cerebral cortex, but not in the nucleus accumbens or striatum. The action of MK-801 to increase c-fos-like immunoreactivity in cerebral cortex was reduced, but not blocked, by SCH-23390. Additionally, MK-801 reduced, but did not eliminate, D1-dopamine agonist induced c-fos-like immunoreactivity in striatum. These data suggest that MK-801 not only can facilitate dopamine release within specific brain regions, but has behavioral and functional actions distinct from dopamine agonists.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 16/07/20 alle ore 06:16:43