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Titolo:
INCREASE IN EXTRACELLULAR ACETYLCHOLINE LEVEL BY SIGMA-LIGANDS IN RATFRONTAL-CORTEX
Autore:
MATSUNO K; MATSUNAGA K; SENDA T; MITA S;
Indirizzi:
SANTEN PHARMACEUT CO LTD,CENT RES LABS,NEW DRUG RES HIGASHIYODOGAWA OSAKA 533 JAPAN
Titolo Testata:
The Journal of pharmacology and experimental therapeutics
fascicolo: 2, volume: 265, anno: 1993,
pagine: 851 - 859
SICI:
0022-3565(1993)265:2<851:IIEALB>2.0.ZU;2-G
Fonte:
ISI
Lingua:
ENG
Soggetto:
GUINEA-PIG BRAIN; STIMULATED PHOSPHOINOSITIDE METABOLISM; PERFORMANCE LIQUID-CHROMATOGRAPHY; PHENCYCLIDINE-LIKE DRUGS; RECEPTOR-BINDING-SITES; HIGHLY SENSITIVE ASSAY; CENTRAL NERVOUS-SYSTEM; FREELY MOVING RATS; MUSCARINIC RECEPTORS; DOPAMINE NEURONS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
69
Recensione:
Indirizzi per estratti:
Citazione:
K. Matsuno et al., "INCREASE IN EXTRACELLULAR ACETYLCHOLINE LEVEL BY SIGMA-LIGANDS IN RATFRONTAL-CORTEX", The Journal of pharmacology and experimental therapeutics, 265(2), 1993, pp. 851-859

Abstract

The effects of sigma ligands on the central acetylcholine (ACh) systems in the rat frontal cortex were examined. By using brain microdialysis techniques, we showed that nonbenzomorphan sigma ligands, (+)-3-(3-hydroxyphenyl)-N-(1-propyl)piperidine and 1,3-di(2-tolyl)guanidine (DTG) dose-dependently increased the extracellular ACh level in this area. Similarly, benzomorphan sigma ligands, (+/-)-pentazocine and (+)-N-allylnormetazocine [(+)-SKF-10,047] also increased the extracellular ACh level. The increase in extracellular ACh level elicited by (+)-SKF-10,047 was greater than that by (-)-SKF-10,047. Moreover, the (+)-SKF-10,047- and DTG-induced increase in the extracellular ACh level were reduced significantly by simultaneous administration of haloperidol, a putative sigma receptor antagonist, whereas the (+)-SKF-10,047-induced increase was unaffected by -)-3-(2-carboxypiperazin-4-yl)-propyl-1-phosphonic acid, a competitive N-methyl-D-aspartate receptor channel antagonist. On the other hand, none of the sigma ligands tested in this study had any effects on acetylcholinesterase or choline acetyltransferase activity and sodium-dependent high affinity choline uptake site in the rat frontal cortex. Ranking of potency for increasing extracellular ACh level was in the following order: (+/-)-pentazocine (+)-SKF-10,047 > (+)-3-(3-hydroxyphenyl)-N-(1-propyl) piperidine > DTG. This orderwas positively correlated with the order of binding potency for the ()-[H-3]SKF-10,047 binding site in the rat frontal cortex, but was notcorrelated with binding to the [H-3]DTG, [H-3]quinuclidinyl benzylateand [H-3]AF-DX116 i-hydro-6H-pyrido[2,3-b][1,4]benzodiazepine-6-one} binding sites. These results suggest that the sigma receptor is involved in regulating the activity of central ACh systems in the rat frontal cortex. The sigma receptor regulating the extracellular ACh level inthe rat frontal cortex was a haloperidol-sensitive, benzomorphan-typesigma receptor.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 30/11/20 alle ore 02:59:00