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Titolo:
FAMILIES AND THE STRUCTURAL RELATEDNESS AMONG GLOBULAR-PROTEINS
Autore:
YEE DP; DILL KA;
Indirizzi:
UNIV CALIF SAN FRANCISCO,DEPT PHARMACEUT CHEM,BOX 1204 SAN FRANCISCO CA 94143 UNIV CALIF SAN FRANCISCO,DEPT PHARMACEUT CHEM,BOX 1204 SAN FRANCISCO CA 94143
Titolo Testata:
Protein science
fascicolo: 6, volume: 2, anno: 1993,
pagine: 884 - 899
SICI:
0961-8368(1993)2:6<884:FATSRA>2.0.ZU;2-O
Fonte:
ISI
Lingua:
ENG
Soggetto:
3-DIMENSIONAL STRUCTURE; BINDING PROTEIN; RESOLUTION; REPRESSOR; PATTERNS; LYSOZYME; TROPONIN; BARREL; FOLD; DNA;
Keywords:
PROTEIN FAMILY; RELATEDNESS; STRUCTURAL COMPARISON; SUBSTRUCTURE SEARCHES;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
30
Recensione:
Indirizzi per estratti:
Citazione:
D.P. Yee e K.A. Dill, "FAMILIES AND THE STRUCTURAL RELATEDNESS AMONG GLOBULAR-PROTEINS", Protein science, 2(6), 1993, pp. 884-899

Abstract

Protein structures come in families. Are families ''closely knit'' or''loosely knit'' entities? We describe a measure of relatedness amongpolymer conformations. Based on weighted distance maps, this measure differs from existing measures mainly in two respects: (1) it is computationally fast, and (2) it can compare any two proteins, regardless of their relative chain lengths or degree of similarity. It does not require finding relative alignments. The measure is used here to determine the dissimilarities between all 12,403 possible pairs of 158 diverse protein structures from the Brookhaven Protein Data Bank (PDB). Combined with minimal spanning trees and hierarchical clustering methods, this measure is used to define structural families. It is also useful for rapidly searching a dataset of protein structures for specific substructural motifs. By using an analogy to distributions of Euclidean distances, we find that protein families are not tightly knit entities.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 28/11/20 alle ore 03:23:46