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Titolo:
A METHOD TO ISOLATE DNA FROM SMALL ARCHIVAL TISSUE SAMPLES FOR P53 GENE ANALYSIS
Autore:
SCHUBERT EL; BISCHOFF FZ; WHITAKER LL; PLEASANTS LM; HANSEN MF;
Indirizzi:
UNIV TEXAS,MD ANDERSON CANC CTR,DEPT MOLEC GENET HOUSTON TX 77030 UNIV TEXAS,MD ANDERSON CANC CTR,DEPT MOLEC GENET HOUSTON TX 77030
Titolo Testata:
Human mutation
fascicolo: 2, volume: 2, anno: 1993,
pagine: 123 - 126
SICI:
1059-7794(1993)2:2<123:AMTIDF>2.0.ZU;2-E
Fonte:
ISI
Lingua:
ENG
Keywords:
ARCHIVAL SAMPLES; MUTATIONAL ANALYSIS; P53; POLYMERASE CHAIN REACTION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
10
Recensione:
Indirizzi per estratti:
Citazione:
E.L. Schubert et al., "A METHOD TO ISOLATE DNA FROM SMALL ARCHIVAL TISSUE SAMPLES FOR P53 GENE ANALYSIS", Human mutation, 2(2), 1993, pp. 123-126

Abstract

The tumor suppressor gene p53 is involved in predisposition to a variety of human cancers, including those from Li-Fraumeni cancer family syndrome patients. Studies of inheritance of p53 germline mutations require confirmation of the mutation in the tumors from family members. These studies, as well as other retrospective studies of tumor specificmutations, are often hampered by a lack of available fresh or frozen tumor tissue samples for DNA extraction to confirm the suspected p53 mutation. Here we describe a simple technique for DNA isolation that permits mutational analysis of p53 from minimal amounts of paraffin-embedded archival tissue samples.

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Documento generato il 24/09/20 alle ore 05:26:42