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Titolo:
ANTIVIRAL THERAPY IN HUMAN-IMMUNODEFICIENCY-VIRUS INFECTIONS - CURRENT STATUS .2.
Autore:
SANDSTROM E; OBERG B;
Indirizzi:
SODER SJUKHUSET,DEPT DERMATOVENEROL S-11883 STOCKHOLM SWEDEN MEDIVIR AB HUDDINGE SWEDEN
Titolo Testata:
Drugs
fascicolo: 5, volume: 45, anno: 1993,
pagine: 637 - 653
SICI:
0012-6667(1993)45:5<637:ATIHI->2.0.ZU;2-Y
Fonte:
ISI
Lingua:
ENG
Soggetto:
AIDS-RELATED COMPLEX; HIV-1 REVERSE-TRANSCRIPTASE; RECOMBINANT SOLUBLE CD4; EPIDEMIC KAPOSIS-SARCOMA; PLACEBO-CONTROLLED TRIAL; SCID-HU MOUSE; PHASE-I; REPLICATION INVITRO; NUCLEOSIDE ANALOGS; ZIDOVUDINE AZT;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
238
Recensione:
Indirizzi per estratti:
Citazione:
E. Sandstrom e B. Oberg, "ANTIVIRAL THERAPY IN HUMAN-IMMUNODEFICIENCY-VIRUS INFECTIONS - CURRENT STATUS .2.", Drugs, 45(5), 1993, pp. 637-653

Abstract

Part I of this article reviewed the targets against which anti-HIV drugs can be directed, problems in assessing active compounds (e.g. resistance development and use of surrogate end-points), and nucleoside analogues effective against HIV reverse transcriptase. Intensive research is currently being undertaken in laboratories and hospitals to design and evaluate new inhibitors of HIV. In this work, combining different drugs is one important approach, both to decrease toxicity and to offset the rate of resistance development, which seems to be a major problem associated with therapy directed against the ever-changing HIV. Therapeutic vaccines and immunomodulators are other modalities being actively evaluated against HIV and AIDS, although this effort has not yet yielded any licensed treatment. It appears likely that new antiviraldrugs and immunotherapies will be forthcoming during the next 5 years, that they will be used in a variety of combinations, and that the treatment options available for opportunistic infections will increase. These developments should improve the survival and the quality of lifeof patients with HIV infection.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 01/12/20 alle ore 10:41:39