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Titolo:
INVOLVEMENT OF THE CATECHOLAMINERGIC SYSTEM IN THE INHIBITORY EFFECT OF BRAIN HISTAMINE ON GROWTH-HORMONE SECRETION
Autore:
SIBILIA V; GUIDOBONO F; PECILE A; PAGANI F; VILLA I; NETTI C;
Indirizzi:
UNIV MILAN,DEPT PHARMACOL CHEMOTHERAPY & MED TOXICOL,VIA VANVITELLI 32 I-20129 MILAN ITALY
Titolo Testata:
Agents and actions
, volume: 38, anno: 1993,
pagine: 272 - 274
SICI:
0065-4299(1993)38:<272:IOTCSI>2.0.ZU;2-Z
Fonte:
ISI
Lingua:
ENG
Soggetto:
RAT;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
5
Recensione:
Indirizzi per estratti:
Citazione:
V. Sibilia et al., "INVOLVEMENT OF THE CATECHOLAMINERGIC SYSTEM IN THE INHIBITORY EFFECT OF BRAIN HISTAMINE ON GROWTH-HORMONE SECRETION", Agents and actions, 38, 1993, pp. 272-274

Abstract

The effects of intracerebroventricular (icy) injection of histamine (HA, 0.4 mumol/rat) or of the inhibitor of HA synthesis alpha-fluoromethylhistidine (alphaFMH, 100 mg/kg, intracarotid (ia)) on growth hormone (GH) secretion induced by GH-releasing hormone (hGHRH1-40, 2 mug/kg,ia) in freely moving rats were examined. HA significantly inhibited GH release induced by GHRH whereas pretreatment (3 h before) with alphaFMH enhanced the GH response to GHRH. The inhibitory effect of HA on GHRH-induced GH release is still evident in somatostatin-depleted rats with cysteamine (300 mg/kg, sc, 4 h before) but is completely overcomeby the inhibitor of catecholamine synthesis (alpha-methyl-p-tyrosine,200 mg/kg, ip, 2 h before) suggesting that HA influences GH secretionby modulation of catecholaminergic neurons. This suggestion is supported by the biochemical data showing an increase in noradrenaline and dopamine contents in the hypothalamus and striatum of rats pretreated with alphaFMH.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 20/02/20 alle ore 00:50:56