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Titolo:
RAPID ACCESS TO PHARMACOKINETICS DATA AND CORRELATION BETWEEN ANTIMICROBIAL SUSCEPTIBILITY RESULTS AND DRUG TISSUE DISTRIBUTION USING A PERSONAL-COMPUTER
Autore:
CORNAGLIA G; ROSSOLINI GM; SATTA G;
Indirizzi:
UNIV VERONA,IST MICROBIOL,STRADA LE GRAZIE 8 I-37134 VERONA ITALY
Titolo Testata:
The New microbiologica
fascicolo: 2, volume: 16, anno: 1993,
pagine: 149 - 164
SICI:
1121-7138(1993)16:2<149:RATPDA>2.0.ZU;2-U
Fonte:
ISI
Lingua:
ENG
Keywords:
PHARMACOKINETICS; ANTIMICROBIAL SUSCEPTIBILITY; PERSONAL COMPUTER;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
NO
Recensione:
Indirizzi per estratti:
Citazione:
G. Cornaglia et al., "RAPID ACCESS TO PHARMACOKINETICS DATA AND CORRELATION BETWEEN ANTIMICROBIAL SUSCEPTIBILITY RESULTS AND DRUG TISSUE DISTRIBUTION USING A PERSONAL-COMPUTER", The New microbiologica, 16(2), 1993, pp. 149-164

Abstract

MYMIC is a computer-aided system capable of integrating antibiotic susceptibility data with the concentrations the drugs reach in various body tissues and fluids by calculating site concentration/minimal inhibitory concentration quotients. The program can be run on any low-cost personal computer operating under MS-DOS, provided it is equipped witha hard-disk drive and with a minimum of 512 kilobytes of random access memory. The use of the program does not require any knowledge of computer languages. The antibiotic susceptibility data can be entered either as minimal inhibitory concentrations or as inhibitory zone diameters; in the latter case, minimal inhibitory concentrations are automatically calculated via regression formulas. The concentrations obtained by 90 antibiotics in 51 different human tissues and fluids are recorded in a data base of over 1,000 records, obtained from roughly 700 original papers. A MYMIC sample session was simulated by mimicking infections of three different body districts (namely bone, prostate, and sputum) caused by Pseudomonas aeruginosa, Escherichia coli or Providencia stuartii.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 18/09/20 alle ore 16:53:43