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Titolo:
COMPARISON AT SARUPLASE AND ALTEPLASE IN ACUTE MYOCARDIAL-INFARCTION
Autore:
BAR FW; MEYER J; VERMEER F; MICHELS R; CHARBONNIER B; HAERTEN K; SPIECKER M; MACAYA C; HANSSEN M; HERAS M; BOLAND JP; MORICE MC; DUNN FG; UEBIS R; HAMM C; AYZENBERG O; STRUPP G; WITHAGEN AJ; KLEIN W; WINDELER J; HOPKINS G; BARTH H; VONFISENNE MJM;
Indirizzi:
UNIV HOSP MAASTRICHT,DEPT CARDIOL,POB 5800 NL-6202 AZ MAASTRICHT NETHERLANDS
Titolo Testata:
The American journal of cardiology
fascicolo: 6, volume: 79, anno: 1997,
pagine: 727 - 732
SICI:
0002-9149(1997)79:6<727:CASAAI>2.0.ZU;2-S
Fonte:
ISI
Lingua:
ENG
Soggetto:
TISSUE-PLASMINOGEN-ACTIVATOR; CORONARY-ARTERY PATENCY; THROMBOLYTIC THERAPY; RT-PA; ELECTROCARDIOGRAPHIC EVIDENCE; CONTROLLED TRIAL; STREPTOKINASE; REPERFUSION; HEPARIN; MULTICENTER;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
27
Recensione:
Indirizzi per estratti:
Citazione:
F.W. Bar et al., "COMPARISON AT SARUPLASE AND ALTEPLASE IN ACUTE MYOCARDIAL-INFARCTION", The American journal of cardiology, 79(6), 1997, pp. 727-732

Abstract

Four hundred seventy-three patients with acute myocardial infarction (AMI) were treated with either saruplase (80 mg/hour, n = 236) or alteplase (100 mg every 3 hours, n = 237). Comedication included heparin and acetylsalicylic acid. Angiography was performed at 45 and 60 minutes after the start of thrombolytic therapy. When flow was insufficient,angiography was repeated at 90 minutes. Coronary angioplasty was thenperformed if Thrombolysis In Myocardial Infarction (TIMI) trial 0 to 1 flow was seen. Control angiography was at 24 to 40 hours. Baseline characteristics were similar. Angiography showed comparable and remarkably high early potency rates (TIMI 2 or 3 flow) in both treatment groups: at 45 minutes, 74.6% versus 68.9% (p = 0.22); and at 60 minutes 79.9% versus 75.3% (p = 0.26). Patency rates at 90 minutes before additional interventions were also comparable (79.9% and 81.4%). Angiographic reocclusion rates were not significantly different: 1.2% versus 2.4%(p = 0.68). After rescue angioplasty, angiographic reocclusion rates of 22.0% and 15.0% were observed. Safety data were similar for both groups. Thus, (1) early patency rates were high for saruplase and alteplase treatment, (2) reocclusion rates for both drugs were remarkably low, and (3) complication rates were similar. Thus, saruplase seems to be as safe and effective as alteplase. (C) 1997 by Excerpta Medica, Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 30/11/20 alle ore 09:52:03