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Titolo:
POTENT STIMULATION OF MONOCYTIC ENDOTHELIN-1 PRODUCTION BY HIV-1 GLYCOPROTEIN-120
Autore:
EHRENREICH H; RIECKMANN P; SINOWATZ F; WEIH KA; ARTHUR LO; GOEBEL FD; BURD PR; COLIGAN JE; CLOUSE KA;
Indirizzi:
UNIV GOTTINGEN,NEUROL KLIN & POLIKLIN,ROBERT KOCH STR 40 W-3400 GOTTINGEN GERMANY NIAID,IMMUNOREGULAT LAB BETHESDA MD 20892 NIAID,CLIN INVEST LAB BETHESDA MD 20892 NIAID,BIOL RESOURCES BRANCH BETHESDA MD 20892 UNIV GOTTINGEN,DEPT NEUROL W-3400 GOTTINGEN GERMANY UNIV GOTTINGEN,DEPT PSYCHIAT W-3400 GOTTINGEN GERMANY UNIV MUNICH,MED POLIKLIN W-8000 MUNICH 2 GERMANY US FDA,CTR BIOLOG EVALUAT & RES BETHESDA MD 20014 NCI,PROGRAM RESOURCES INC DYN CORP FREDERICK MD 21701
Titolo Testata:
The Journal of immunology
fascicolo: 10, volume: 150, anno: 1993,
pagine: 4601 - 4609
SICI:
0022-1767(1993)150:10<4601:PSOMEP>2.0.ZU;2-C
Fonte:
ISI
Lingua:
ENG
Soggetto:
HUMAN-IMMUNODEFICIENCY-VIRUS; CENTRAL-NERVOUS-SYSTEM; AIDS DEMENTIA COMPLEX; IMMUNE-DEFICIENCY-SYNDROME; CEREBRAL-ARTERIES; ENVELOPE PROTEIN; GLIAL-CELLS; SOLUBLE CD4; MACROPHAGES; INFECTION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
51
Recensione:
Indirizzi per estratti:
Citazione:
H. Ehrenreich et al., "POTENT STIMULATION OF MONOCYTIC ENDOTHELIN-1 PRODUCTION BY HIV-1 GLYCOPROTEIN-120", The Journal of immunology, 150(10), 1993, pp. 4601-4609

Abstract

Monocytes/macrophages play a critical role in the pathogenesis of HIVinfection, both as targets for virus replication and as sources of production of multifunctional cytokines. Endothelins, peptides with potent vasoconstricting activities originally isolated from endothelial cells, are also produced and secreted by macrophages in a manner similarto that of other cytokines. In an attempt to explore the potential role of endothelins in HIV-infection, we investigated the effect of the HIV-1 envelope glycoprotein, glycoprotein 120, on monocytic endothelin-1 production. This glycoprotein has been identified as a potent stimulator of monokines such as TNF-alpha and IL-6, which have been implicated as potential mediators of HIV-encephalopathy. We found that glycoprotein 120, similar to LPS, stimulates the secretion of endothelin-1, as well as TNF-alpha, from macrophages in a concentration-dependent manner. Using reverse transcriptase polymerase chain reaction, we found that circulating monocytes in HIV-infected individuals show a distinctexpression of the endothelin-1 gene that is not detectable in healthycontrols, indicating chronic activation of this gene in HIV-infection. In addition, cerebral macrophages in patients with HIV-encephalopathy were strongly positive for endothelin. Thus, monocytic endothelins appear to be stimulated during HIV infection. Their potent vasoactive properties render them potential candidates for mediating alterations in the cerebral perfusion pattern associated with the AIDS dementia complex.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 03/12/20 alle ore 14:56:38