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Titolo:
NEONATAL COCHLEAR HEARING-LOSS RESULTS IN DEVELOPMENTAL ABNORMALITIESOF THE CENTRAL AUDITORY PATHWAYS
Autore:
HARRISON RV; STANTON SG; IBRAHIM D; NAGASAWA A; MOUNT RJ;
Indirizzi:
HOSP SICK CHILDREN,DEPT OTOLARYNGOL,AUDITORY SCI LAB,555 UNIV AVE TORONTO M5G 1X8 ONTARIO CANADA UNIV TORONTO,DEPT PHYSIOL TORONTO M5S 1A1 ONTARIO CANADA UNIV TORONTO,INST BIOMED ENGN TORONTO M5S 1A1 ONTARIO CANADA
Titolo Testata:
Acta oto-laryngologica
fascicolo: 3, volume: 113, anno: 1993,
pagine: 296 - 302
SICI:
0001-6489(1993)113:3<296:NCHRID>2.0.ZU;2-8
Fonte:
ISI
Lingua:
ENG
Soggetto:
CORTEX; REORGANIZATION; ORGANIZATION; ABLATION; NERVE; CAT;
Keywords:
COCHLEAR HEARING LOSS; COCHLEOTOPIC ORGANIZATION; DEVELOPMENTAL PLASTICITY; INFERIOR COLLICULUS; PRIMARY AUDITORY CORTEX; ELECTROPHYSIOLOGICAL STUDIES;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
23
Recensione:
Indirizzi per estratti:
Citazione:
R.V. Harrison et al., "NEONATAL COCHLEAR HEARING-LOSS RESULTS IN DEVELOPMENTAL ABNORMALITIESOF THE CENTRAL AUDITORY PATHWAYS", Acta oto-laryngologica, 113(3), 1993, pp. 296-302

Abstract

We have used animal models of long term neonatal cochlear hearing loss to study developmental plasticity of the central auditory pathways. Newborn chinchilla pups and feline kittens were treated with the ototoxic drug amikacin, so as to induce basal lesions in the cochlea. At maturity these animals were used in single unit electrophysiological mapping studies, in which the cochleotopic organization of primary auditory cortex (of the cat) and the inferior colliculus of the midbrain (inthe chinchilla) were mapped. We have observed, both in the midbrain and auditory cortex, massive reorganization of frequency representation. Most striking were the presence of large monotonic regions (i.e. large areas in which all neurons have similar tuning properties). Cochlear lesions which involve inner haircells clearly modify the normal development of cochleotopic representation in the midbrain and cortical regions. We suggest that similar abnormal patterns of frequency representation will exist in human subjects with long term neonatal hearing loss.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 21/09/20 alle ore 11:34:13