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Titolo:
A COMPARISON OF ONCE-DAILY ATENOLOL AND METOPROLOL USING OFFICE AND AMBULATORY BLOOD-PRESSURE MONITORING
Autore:
RUTAN GH; FEIG PU; MAY S; KRIEGMAN AG; BRADY EM;
Indirizzi:
MEMPHIS DVAMC,AMBULATORY CARE 11C,1030 JEFFERSON AVE MEMPHIS TN 38104 DEPT VET AFFAIRS MEMPHIS TN 00000 UNIV PITTSBURGH,DEPT EPIDEMIOL PITTSBURGH PA 15260 CIBA GEIGY CORP SUMMIT NJ 07901 JANSSEN PHARMACEUT TITUSVILLE NJ 00000 UNIV TENNESSEE,DEPT MED KNOXVILLE TN 37996 UNIV TENNESSEE,DEPT PREVENT MED KNOXVILLE TN 37996 MILES INC,DIV PHARMACEUT W HAVEN CT 00000
Titolo Testata:
Journal of clinical pharmacology
fascicolo: 5, volume: 33, anno: 1993,
pagine: 418 - 426
SICI:
0091-2700(1993)33:5<418:ACOOAA>2.0.ZU;2-2
Fonte:
ISI
Lingua:
ENG
Soggetto:
HYPERTENSIVE PATIENTS; CIRCADIAN VARIATION; BLOCKING-AGENTS; HEART-RATE; FREQUENCY;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
21
Recensione:
Indirizzi per estratti:
Citazione:
G.H. Rutan et al., "A COMPARISON OF ONCE-DAILY ATENOLOL AND METOPROLOL USING OFFICE AND AMBULATORY BLOOD-PRESSURE MONITORING", Journal of clinical pharmacology, 33(5), 1993, pp. 418-426

Abstract

The authors compared the relative safety and efficacy of changing treatment from once-daily atenolol to metoprolol in patients with essential hypertension. A parallel-group randomized clinical trial was conducted in two phases: a 4-week baseline single-blind phase using atenolol50 mg, followed by a 4-week randomized double-blind treatment phase using either atenolol 50 mg or metoprolol 100 mg administered once daily at noontime. Patients with well-controlled hypertension already prescribed 50 mg of atenolol (with or without the addition of a diuretic) for control of hypertension were selected for participation from the outpatient hypertension clinic of the Department of Veterans Affairs Medical Center, Pittsburgh, Pennsylvania. Seated blood pressure (BP) andpulse were obtained during the baseline phase and during the randomized treatment phase. Twenty-four-hour ambulatory BP monitoring was performed once during the baseline phase and once during the randomized treatment phase, near the end of each 4-week period. There were no within- and between-treatment differences in office systolic and diastolic BP. There was a slight increase in pulse (average = 5.2 beats/minute; P = .02) for those participants treated with metoprolol. For within-treatment groups, the ambulatory BP data showed no significant differences in systolic and diastolic BPs, except for an increase in morning diastolic BP for those randomized to metoprolol (average = 6.2 mm Hg; P = .01). For between-treatment groups, the metoprolol arm had a higher morning systolic BP (P = .01), a higher morning diastolic BP (P = .03), and a higher nighttime heart rate (P = .01). There were no study withdrawals due to adverse events. Once-daily administration of both atenolol and metoprolol appear to control BP as measured by office and ambulatory monitoring techniques, but atenolol appears to maintain BP control more effectively than metoprolol during the end of the dosing interval.

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Documento generato il 02/12/20 alle ore 14:48:37