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Titolo:
LACK OF ASSOCIATION BETWEEN SCHIZOPHRENIA AND ALLELES IN THE DOPAMINE-D3 RECEPTOR GENE
Autore:
JONSSON E; LANNFELT L; SOKOLOFF P; SCHWARTZ JC; SEDVALL G;
Indirizzi:
KAROLINSKA HOSP,DEPT PSYCHIAT & PSYCHOL S-10401 STOCKHOLM 60 SWEDEN KAROLINSKA INST,DEPT PSYCHIAT & PSYCHOL S-10401 STOCKHOLM 60 SWEDEN HUDDINGE HOSP,DEPT GERIATR MED S-14186 HUDDINGE SWEDEN INSERM,U109,UNITE NEUROBIOL & PHARMACOL F-75005 PARIS FRANCE
Titolo Testata:
Acta psychiatrica Scandinavica
fascicolo: 5, volume: 87, anno: 1993,
pagine: 345 - 349
SICI:
0001-690X(1993)87:5<345:LOABSA>2.0.ZU;2-2
Fonte:
ISI
Lingua:
ENG
Soggetto:
MONOAMINE METABOLITES; CEREBROSPINAL-FLUID; ALCOHOLISM; LOCALIZATION; LINKAGE; CLONING; LOCUS;
Keywords:
SCHIZOPHRENIA; GENETICS; ASSOCIATION; DOPAMINE-D3 RECEPTOR GENE LOCUS; DOPAMINE RECEPTOR;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Social Sciences Citation Index
Science Citation Index Expanded
Citazioni:
26
Recensione:
Indirizzi per estratti:
Citazione:
E. Jonsson et al., "LACK OF ASSOCIATION BETWEEN SCHIZOPHRENIA AND ALLELES IN THE DOPAMINE-D3 RECEPTOR GENE", Acta psychiatrica Scandinavica, 87(5), 1993, pp. 345-349

Abstract

Dopamine receptor dysfunction has been implicated in the pathophysiology of schizophrenia. Schizophrenic patients (n = 76) and control subjects (n = 53) were examined for allele frequencies in a 2-allele BalI polymorphism, causing a serine --> glycine amino acid substitution in the coding sequence of the dopamine D3 receptor gene. No statistical significant differences of allele frequencies or genotype frequencies could be found between the two groups. Neither were there any significant relationships between allele frequencies and a number of clinical variables within the schizophrenic subsample. However, if not correctedfor multiple testing, an association was found between homozygosity and positive response to neuroleptic drugs. The present study does not provide evidence that the BalI polymorphism in the dopamine D3 receptor gene is involved in the pathophysiology of schizophrenia. Further investigations with an increased number and variety of patients concerning response to neuroleptic drugs and expression of the receptor in human brain should be performed to definitively exclude this hypothesis.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 14/08/20 alle ore 17:06:27