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Titolo:
EFFICACY OF DIAZEPAM AND MEPERIDINE IN AMBULATORY PEDIATRIC-PATIENTS UNDERGOING ENDOSCOPY - A RANDOMIZED, DOUBLE-BLIND TRIAL
Autore:
BAHALOMARA N; NAHATA MC; MURRAY RD; LINSCHEID TR; WILLIAMS T; HEITLINGER LA; LI BUK; MCCLUNG HJ; LININGER B;
Indirizzi:
OHIO STATE UNIV,COLL PHARM,WEXNER INST PEDIAT RES,500 W 12 AVE COLUMBUS OH 43210 OHIO STATE UNIV,COLL PHARM,WEXNER INST PEDIAT RES,500 W 12 AVE COLUMBUS OH 43210 OHIO STATE UNIV,COLL MED COLUMBUS OH 43210 CHILDRENS HOSP COLUMBUS OH 43205
Titolo Testata:
Journal of pediatric gastroenterology and nutrition
fascicolo: 4, volume: 16, anno: 1993,
pagine: 387 - 392
SICI:
0277-2116(1993)16:4<387:EODAMI>2.0.ZU;2-D
Fonte:
ISI
Lingua:
ENG
Soggetto:
UPPER GASTROINTESTINAL ENDOSCOPY; SEDATION; MIDAZOLAM; CHILDREN;
Keywords:
MEPERIDINE; DIAZEPAM; ENDOSCOPY; SEDATION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
15
Recensione:
Indirizzi per estratti:
Citazione:
N. Bahalomara et al., "EFFICACY OF DIAZEPAM AND MEPERIDINE IN AMBULATORY PEDIATRIC-PATIENTS UNDERGOING ENDOSCOPY - A RANDOMIZED, DOUBLE-BLIND TRIAL", Journal of pediatric gastroenterology and nutrition, 16(4), 1993, pp. 387-392

Abstract

Medications are routinely administered to children prior to upper gastrointestinal endoscopy procedures. We evaluated the efficacy and safety of four dosage regimens: meperidine 2 mg/kg (M); low-dose meperdine1 mg/kg and diazepam 0.1 mg/kg (M low + D); high-dose meperidine 2 mg/kg and diazepam 0.1 mg/kg (M high + D); and, diazepam 0.1 mg/kg (D) in a randomized, double-blind trial in 71 pediatric patients (ages 1 to19 years). Cooperation, emotional state, and sedation were rated. Thefrequency of negative behavior demonstration (i.e., crying, gagging, flailing, nervous behavior) indicating ineffective or inadequate sedation was recorded before, during, and after the procedure, Vital signs and oxygen saturation were noted. Significant differences were observed in the efficacy of the various sedation regimens. Overall, the physicians and nurses rated M most effective in children <11 years. In these children, M high + D and D were rated least effective by the nurses,whereas physicians felt that D was least effective. In the older children, M, M low + D, and M high + D were rated similarly effective by physicians and nurses, and D was rated least effective. In both age groups, the lowest incidence of negative behaviors during the endoscopy procedure occurred in patients who received M. Combinations of D and M D resulted in an increased incidence of negative behaviors; thus, M may be the preferred sedation regimen in children undergoing endoscopy. The addition of diazepam to meperidine may be detrimental in terms of eliciting negative behaviors.

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Documento generato il 02/07/20 alle ore 20:36:30