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Titolo:
DEGREE OF PROTEIN-DEFICIENCY AFFECTS THE EXTENT OF THE DEPRESSION OF THE ANTIOXIDATIVE ENZYME-ACTIVITIES AND THE ENHANCEMENT OF TISSUE LIPID-PEROXIDATION IN RATS
Autore:
HUANG CJ; FWU ML;
Indirizzi:
NATL TAIWAN UNIV,DEPT AGR CHEM TAIPEI 10764 TAIWAN
Titolo Testata:
The Journal of nutrition
fascicolo: 5, volume: 123, anno: 1993,
pagine: 803 - 810
SICI:
0022-3166(1993)123:5<803:DOPATE>2.0.ZU;2-9
Fonte:
ISI
Lingua:
ENG
Soggetto:
URINARY ASCORBIC-ACID; DIETARY VITAMIN-E; GLUTATHIONE-PEROXIDASE; OXYGEN-TOXICITY; FED PCB; LIVER; RESTRICTION; SELENIUM; ASSAY;
Keywords:
RATS; LIPID PEROXIDATION; DIETARY PROTEIN; ANTIOXIDATIVE ENZYMES;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
37
Recensione:
Indirizzi per estratti:
Citazione:
C.J. Huang e M.L. Fwu, "DEGREE OF PROTEIN-DEFICIENCY AFFECTS THE EXTENT OF THE DEPRESSION OF THE ANTIOXIDATIVE ENZYME-ACTIVITIES AND THE ENHANCEMENT OF TISSUE LIPID-PEROXIDATION IN RATS", The Journal of nutrition, 123(5), 1993, pp. 803-810

Abstract

To investigate the effects of various dietary protein levels on tissue lipid peroxidation and antioxidative enzyme activities, four groups of Long-Evans male weanling rats were fed a 6, 8, 12 or 20% lactalbumin diet for 6 wk. The red blood cell in vitro spontaneous hemolysis values were 28.6, 24.9, 18.9 and 14.1% for the rats fed the 6, 8, 12 and 20% lactalbumin diets, respectively. The thiobarbituric acid-reactive substances (TBARS) in plasma, RBC, liver, kidney, muscle, lung, spleenand heart were lowest in the group fed the 20% lactalbumin diet. Ratsfed the diet containing 12% lactalbumin had significantly greater TBARS in plasma, spleen, kidney and muscle compared with rats fed the 20%lactalbumin diet. Rats fed the 8% lactalbumin diet had markedly higher TBARS levels (P < 0.05) in all tissues examined than did those fed the 12% lactalbumin diet. The TBARS in all eight tissues of the rats fed the 6% lactalbumin diet were even higher than those of rats fed the 8% lactalbumin diet (P < 0.05). The activities of glutathione peroxidase, superoxide dismutase and glucose-6-phosphate dehydrogenase in RBC were gradually lowered (P < 0.05) when the dietary protein level was decreased stepwise. The activities of these antioxidative enzymes in liver also were reduced significantly when dietary protein level decreased from 20 to 12% and then to 8%. These enzyme activities in the rats fed the diet containing 6% lactalbumin generally were not different from those of the rats fed 8% lactalbumin. Thus, the degree of protein deficiency affects the extent of the depression of the antioxidative enzyme activities and the enhancement of tissue lipid peroxidation.

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Documento generato il 27/11/20 alle ore 02:07:27