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Titolo:
THE CORRELATED BLANCHING OF SYNAPTIC BODIES AND REDUCTION IN AFFERENTFIRING RATES CAUSED BY TRANSMITTER-DEPLETING AGENTS IN THE FROG SEMICIRCULAR CANAL
Autore:
GUTH P; NORRIS C; FERMIN CD; PANTOJA M;
Indirizzi:
TULANE UNIV,SCH MED,DEPT PHARMACOL,1430 TULANE AVE,RM 3730 NEW ORLEANS LA 70112 TULANE UNIV,SCH MED,DEPT OTOLARYNGOL NEW ORLEANS LA 70112 TULANE UNIV,SCH MED,DEPT PATHOL NEW ORLEANS LA 70112 UNIV VALLE,DEPT PHARMACOL CALI COLOMBIA
Titolo Testata:
Hearing research
fascicolo: 2, volume: 66, anno: 1993,
pagine: 143 - 149
SICI:
0378-5955(1993)66:2<143:TCBOSB>2.0.ZU;2-H
Fonte:
ISI
Lingua:
ENG
Soggetto:
HAIR-CELLS; ORGAN; CORTI; SYNAPSES; MEMBRANE; MICE;
Keywords:
SYNAPTIC BODIES; HAIR CELLS; POSTERIOR CRISTA; FROG; SEMICIRCULAR CANAL; VESTIBULAR;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
29
Recensione:
Indirizzi per estratti:
Citazione:
P. Guth et al., "THE CORRELATED BLANCHING OF SYNAPTIC BODIES AND REDUCTION IN AFFERENTFIRING RATES CAUSED BY TRANSMITTER-DEPLETING AGENTS IN THE FROG SEMICIRCULAR CANAL", Hearing research, 66(2), 1993, pp. 143-149

Abstract

Synaptic bodies (SBs) associated with rings of synaptic vesicles and well-defined, pre-and post-synaptic membrane structures are indicatorsof maturity in most hair cell-afferent nerve junctions. The role of the SBs remains elusive despite several experiments showing that they may be involved in storage of neurotransmitter. Our results demonstratethat SBs of the adult posterior semicircular canal (SCC) cristae haircells become less electron dense following incubation of the SCC withthe transmitter-depleting drug tetrabenazine (TBZ). Objective quantification and comparison of the densities of the SBs in untreated and TBZ-treated frog SCC demonstrated that TBZ significantly decreased the electron density of SBs. This reduction in electron density was accompanied by a reduction in firing rates of afferent fibers innervating theposterior SCC. A second transmitter-depleting drug, guanethidine, previously shown to reduce the electron density of hair cell SBs, also reduced the firing rates of afferent fibers innervating the posterior SCC. In contrast, the electron density of dense granules (DG), similar in size and shape to synaptic bodies (SB) in hair cells, did not changeafter incubation in TBZ, thus indicating that granules and SBs are not similar in regard to their electron density. The role of SBs in synaptic transmission and the transmitter, if any, stored in the SBs remain unknown. Nonetheless, the association of the lessening of electron density with a reduction in afferent firing rate provides impetus for the further investigation of the SB's role in neurotransmission.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 16/07/20 alle ore 06:40:36