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Titolo:
THE ROLE OF CYTOKINES IN THE PATHOGENESIS OF HEPATIC GRANULOMATOUS-DISEASE IN SCHISTOSOMA-MANSONI INFECTED MICE
Autore:
CHEEVER AW; XU YH; MACEDONIA JG; COX T; HIENY S; SHER A;
Indirizzi:
NIAID,PARASIT DIS LAB BETHESDA MD 20892
Titolo Testata:
Memorias do Instituto Oswaldo Cruz
, volume: 87, anno: 1992, supplemento:, 4
pagine: 81 - 85
SICI:
0074-0276(1992)87:<81:TROCIT>2.0.ZU;2-B
Fonte:
ISI
Lingua:
ENG
Soggetto:
SUPPRESSOR EFFECTOR FACTOR; MOLECULAR-BASIS; LYMPHOCYTES-T; IL-2;
Keywords:
SCHISTOSOMA MANSONI; CYTOKINES; PATHOGENESIS; IL-2; IL-4; IL-5; IFN-GAMMA;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
15
Recensione:
Indirizzi per estratti:
Citazione:
A.W. Cheever et al., "THE ROLE OF CYTOKINES IN THE PATHOGENESIS OF HEPATIC GRANULOMATOUS-DISEASE IN SCHISTOSOMA-MANSONI INFECTED MICE", Memorias do Instituto Oswaldo Cruz, 87, 1992, pp. 81-85

Abstract

Cytokines are important in the cell-mediated response to Schistosoma mansoni eggs. We have found that Th2 cytokine responses (e.g. IL-4 andIL-5) are augmented after egg laying begins while Th1 responses (IL-2and IFN-gamma) are down regulated in S. mansoni infected mice. Treatment of mice with anti-IL-5 monoclonal antibodies (Mab) suppressed the eosinophil response almost completely but did not affect granuloma size and slightly increased hepatic fibrosis. Anti-IL-4 treatment abolished IgE responses in infected mice and decreased hepatic fibrosis slightly. Anti-IFN-gamma treatment had no effect on hepatic pathology. Anti-IL-2 treatment decreased granuloma size significantly and decreased hepatic fibrosis markedly. Anti-IL-2 treatment dramatically decreased IL-5 secretion by splenic cells in vitro and decreased peripheral bloodand tissue eosinophilia. In contrast IL-4 secretion was unaffected and serum IgE was normal or increased. IL-2 and IFN-gamma secretion by splenic cells of treated mice were slightly but not significantly increased suggesting that anti-IL-2 treatment is affecting Th2 rather than Th1 responses.

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Documento generato il 27/11/20 alle ore 22:15:02