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Titolo:
THE EFFECT OF MAGNESIUM VERSUS VERAPAMIL ON SUPRAVENTRICULAR ARRHYTHMIAS
Autore:
GULLESTAD L; BIRKELAND K; MOLSTAD P; HOYER MM; VANBERG P; KJEKSHUS J;
Indirizzi:
NATL HOSP NORWAY,DEPT MED B N-0027 OSLO 1 NORWAY BAERUM HOSP,DEPT INTERNAL MED OSLO NORWAY HAMAR HOSP,DEPT INTERNAL MED OSLO NORWAY
Titolo Testata:
Clinical cardiology
fascicolo: 5, volume: 16, anno: 1993,
pagine: 429 - 434
SICI:
0160-9289(1993)16:5<429:TEOMVV>2.0.ZU;2-0
Fonte:
ISI
Lingua:
ENG
Soggetto:
ACUTE MYOCARDIAL-INFARCTION; ATRIAL-FIBRILLATION; SINUS RHYTHM; INTRAVENOUS MAGNESIUM; CARDIAC-ARRHYTHMIAS; DIGITALIS TOXICITY; FLECAINIDE; TACHYCARDIA; TACHYARRHYTHMIAS; CONVERSION;
Keywords:
ARRHYTHMIAS; ATRIAL FIBRILLATION; ATRIAL FLUTTER; MAGNESIUM SULFATE; VERAPAMIL;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
46
Recensione:
Indirizzi per estratti:
Citazione:
L. Gullestad et al., "THE EFFECT OF MAGNESIUM VERSUS VERAPAMIL ON SUPRAVENTRICULAR ARRHYTHMIAS", Clinical cardiology, 16(5), 1993, pp. 429-434

Abstract

Magnesium has previously been used in the treatment of various arrhythmias, but few randomized and prospective studies are available. In a single-blind study, the efficacy and safety of intravenous magnesium sulfate (bolus doses of 5 + 5 mmol followed by infusion of 0.04 mmol/min) versus verapamil (5 + 5 mg followed by 0.1 mg/min) was evaluated in57 patients with supraventricular arrhythmias (supraventricular tachycardia, atrial fibrillation, and atrial flutter) of recent onset (lessthan 1 week). Fifteen (58%) of the patients receiving magnesium (n = 26) converted to sinus rhythm within 4 h, and 16 (62%) within 24 h. Verapamil caused a lower ventricular rate, but only six (19%) of the patients (n = 31) converted to sinus rhythm within 4 h (p < 0.01) and 16 (52%) within 24 h (NS). No side effects were observed during magnesiuminfusion, whereas six patients receiving verapamil had to be withdrawn from further study medication due to symptomatic side effects (hypotension in three, cardiac failure in three). Magnesium appears to be aneffective and safe drug for the treatment of supraventricular arrhythmias. The overall efficacy for conversion to sinus rhythm is at least as effective as with verapamil, and its action is more rapid.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 01/12/20 alle ore 11:01:13