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Titolo:
COXSACKIE B3 MYOCARDITIS INDUCES A DECREASE IN ENERGY-CHARGE AND ACCUMULATION OF HYALURONAN IN THE MOUSE HEART
Autore:
WALDENSTROM A; FOHLMAN J; ILBACK NG; RONQUIST G; HALLGREN R; GERDIN B;
Indirizzi:
UNIV HOSP UPPSALA,DEPT INTERNAL MED S-75185 UPPSALA SWEDEN UNIV HOSP UPPSALA,DEPT INFECT DIS S-75185 UPPSALA SWEDEN UNIV HOSP UPPSALA,DEPT CLIN CHEM S-75185 UPPSALA SWEDEN UNIV HOSP UPPSALA,DEPT SURG S-75185 UPPSALA SWEDEN MED PROD AGCY UPPSALA SWEDEN
Titolo Testata:
European journal of clinical investigation
fascicolo: 5, volume: 23, anno: 1993,
pagine: 277 - 282
SICI:
0014-2972(1993)23:5<277:CBMIAD>2.0.ZU;2-D
Fonte:
ISI
Lingua:
ENG
Soggetto:
RAT-HEART; DILATED CARDIOMYOPATHY; TRANSPLANTATION EDEMA; DIAGNOSTIC RELEVANCE; VIRAL MYOCARDITIS; IMMUNE-REACTIONS; INFARCT SIZE; ACID; ANTIBODIES; ACTIVATION;
Keywords:
ADENINE NUCLEOTIDES; ENERGY CHARGE; HYALURONIC ACID; INFLAMMATION; MYOCARDITIS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
45
Recensione:
Indirizzi per estratti:
Citazione:
A. Waldenstrom et al., "COXSACKIE B3 MYOCARDITIS INDUCES A DECREASE IN ENERGY-CHARGE AND ACCUMULATION OF HYALURONAN IN THE MOUSE HEART", European journal of clinical investigation, 23(5), 1993, pp. 277-282

Abstract

Interstitial oedema in chronic inflammation and ischaemia is related to an accumulation of hyaluronan (hyaluronic acid; HA) in the interstitium. As interstitial oedema will affect the oxygen transport in the interstitium we have evaluated whether accumulation of HA is related tosigns of myocardial energy depletion in virus induced myocarditis. Myocarditis was induced in Balb/c mice by inoculation of Coxsackie B3 virus. The extractable HA content of the myocardium increased progressively from a baseline value of 153 +/- 26 mug g-1 dry weight to a maximum of 286 +/- 78 mug g-1 dry weight at day 7, whereafter there was a slight decline. Affinity histochemistry visualized HA in the endo-perimysium in healthy myocardium. At day 5 after Coxsackie B3 inoculation there was a general widening of the endomysium, which exhibited a positive staining for HA. In conjunction with focal inflammatory infiltratesthe staining for HA was even more pronounced. The energy rich adenylates were reversibly affected by the Coxsackie B3 infection. There was a slight, but significant decline in EC from 0.74 +/- 0.05 in the control group to a minimum value of 0.64 +/- 0.10 at day 5, whereafter a restitution was observed at days 7 and 10. The total adenine nucleotidepool was similarly decreased from 27.8 +/- 2.9 mumol g-1 dry weight in controls to 24.6 +/- 2.1 mug g-1 dry weight at day 5, and normalizedat days 7 and 10. The data suggest that virus induced myocarditis is associated with a local accumulation of HA in the myocardium. Accumulation of HA is reasonably not a major pathophysiological component in the disturbed energy metabolism seen, but may be of interest for genesis of arrhythmias and possibly sudden death.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 30/11/20 alle ore 16:51:41