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Titolo:
PROTECTION OF ZINC ACEXAMATE ON GASTRIC-LESIONS INDUCED BY NONSTEROIDAL ANTIINFLAMMATORY DRUGS
Autore:
NAVARRO C; BRAVO L; BULBENA O;
Indirizzi:
LABS VINAS SA,DEPT FARMACOL BARCELONA SPAIN
Titolo Testata:
Revista espanola de enfermedades digestivas
fascicolo: 3, volume: 83, anno: 1993,
pagine: 156 - 160
SICI:
1130-0108(1993)83:3<156:POZAOG>2.0.ZU;2-D
Fonte:
ISI
Lingua:
SPA
Keywords:
ZINC ACEXAMATE; ANTIINFLAMMATORY DRUGS; GASTRIC LESIONS; PROSTAGLANDIN-E2;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
NO
Recensione:
Indirizzi per estratti:
Citazione:
C. Navarro et al., "PROTECTION OF ZINC ACEXAMATE ON GASTRIC-LESIONS INDUCED BY NONSTEROIDAL ANTIINFLAMMATORY DRUGS", Revista espanola de enfermedades digestivas, 83(3), 1993, pp. 156-160

Abstract

The ability of different non-steroidal anti-inflammatory drugs (diclofenac, indomethacin, ketoprofen, naproxen and piroxicam) to inhibit gastric prostaglandin E2 production in the rat was compared with their damaging potential on gastric mucosa. The influence of treatment with zinc acexamate (ZAC) on these two parameters was also determined. ZAC treatment significantly decreased the degree of gastric damage elicitedby all the antiinflammatories tested. The experimental data confirm the complexity of the gastrolesive effect exerted by anti-inflammatory drugs and that only part of such effect would be related with their inhibition of prostaglandin synthesis. These results indicate that the gastroprotection of ZAC does not exclusively depend on the effect on the synthesis of prostaglandins by the gastric mucosa, yet it can additionally be exerted through alternative mechanisms.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 02/12/20 alle ore 05:06:49