Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
DOSIMETRY OF INTRAPERITONEALLY ADMINISTERED RADIOLABELED ANTIBODIES
Autore:
ROESKE JC; CHEN GTY; BRILL AB;
Indirizzi:
UNIV CHICAGO,CTR RADIAT THERAPY,DEPT RADIAT & CELLULAR ONCOL CHICAGO IL 60637 UNIV MASSACHUSETTS WORCESTER MA 01605
Titolo Testata:
Medical physics
fascicolo: 2, volume: 20, anno: 1993,
parte:, 2
pagine: 593 - 600
SICI:
0094-2405(1993)20:2<593:DOIARA>2.0.ZU;2-9
Fonte:
ISI
Lingua:
ENG
Soggetto:
OC-125 MONOCLONAL-ANTIBODY; ADVANCED OVARIAN-CANCER; QUANTITATIVE AUTORADIOGRAPHY; PERITONEAL-CAVITY; MODELING ANALYSIS; TUMOR UPTAKE; RADIOIMMUNOTHERAPY; RADIATION; BIODISTRIBUTION; BINDING;
Keywords:
INTRAPERITONEAL RADIOIMMUNOTHERAPY; DOSIMETRY; MODELS; ALPHA-EMITTER AND BETA-EMITTER;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
51
Recensione:
Indirizzi per estratti:
Citazione:
J.C. Roeske et al., "DOSIMETRY OF INTRAPERITONEALLY ADMINISTERED RADIOLABELED ANTIBODIES", Medical physics, 20(2), 1993, pp. 593-600

Abstract

Intraperitoneal and intracavitary radioimmunotherapy differ from other approaches of radioimmunotherapy in that high activity and dose gradients exist near the solution/tumor interface. Dose to tumor and normal tissue at the interface is a function of depth and is due to three major components: (1) the activity concentration of the administered radiolabeled antibody solution as a function of time within the compartment; (2) the spatial distribution of antibody/radionuclide complex as a function of depth and time as the biomolecules bind to and permeate tumor/normal tissues; and (3) the physical characteristics of the radionuclide in relation to depth of antibody penetration. In this review,the biological and physical aspects of intraperitoneally administeredradiolabeled antibodies are discussed, and the state of experimental and calculational studies for this site is described. Areas requiring future investigation are examined, and recommendations are made regarding the type of measurements and calculations which are required for accurate dosimetry.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 25/01/21 alle ore 15:53:15