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Titolo:
QUANTITATIVE-ANALYSIS OF SKELETAL-MUSCLE BIOENERGETICS AND PROTON EFFLUX IN MIGRAINE AND CLUSTER HEADACHE
Autore:
LODI R; KEMP GJ; MONTAGNA P; PIERANGELI G; CORTELLI P; IOTTI S; RADDA GK; BARBIROLI B;
Indirizzi:
JOHN RADCLIFFE HOSP,MRC,BIOCHEM & CLIN MAGNET RESONANCE UNIT OXFORD OX3 9DU ENGLAND UNIV BOLOGNA,DIPARTIMENTO MED CLIN & BIOTECNOL APPLICATA D CAM,CATTEDRA BIOCHIM CLIN BOLOGNA ITALY UNIV BOLOGNA,IST CLIN NEUROL BOLOGNA ITALY
Titolo Testata:
Journal of the neurological sciences
fascicolo: 1, volume: 146, anno: 1997,
pagine: 73 - 80
SICI:
0022-510X(1997)146:1<73:QOSBAP>2.0.ZU;2-K
Fonte:
ISI
Lingua:
ENG
Soggetto:
MAGNETIC-RESONANCE SPECTROSCOPY; MITOCHONDRIAL OXIDATIVE-PHOSPHORYLATION; BRAIN ENERGY-METABOLISM; P-31 MRS; ABNORMAL BRAIN; POINT MUTATION; EXERCISE; RECOVERY; MAGNESIUM; AURA;
Keywords:
IN VIVO P-31-MRS; MIGRAINE; CLUSTER HEADACHE; SKELETAL MUSCLE; BIOENERGETICS; PROTON EFFLUX; NORMAL CONTROLS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
47
Recensione:
Indirizzi per estratti:
Citazione:
R. Lodi et al., "QUANTITATIVE-ANALYSIS OF SKELETAL-MUSCLE BIOENERGETICS AND PROTON EFFLUX IN MIGRAINE AND CLUSTER HEADACHE", Journal of the neurological sciences, 146(1), 1997, pp. 73-80

Abstract

Phosphorus MR spectroscopy (P-31-MRS) was used to quantify skeletal muscle bioenergetics and proton efflux in 63 patients with migraine (23with migraine without aura, MwoA, 22 with migraine with aura, MwA, and 18 with prolonged aura or stroke, CM) and in 14 patients with cluster headache (CH), all in an attack-free period. At rest mitochondrial function was abnormal only in CM, as shown by a low phosphocreatine (PCr) concentration. At the end of a mixed glycolytic/aerobic exercise all three migraine groups showed a significantly smaller decrease of cytosolic pH compared to controls with a similar end-exercise PCr breakdown, while end-exercise pH was normal in cluster headache patients. Thenormal rate of proton efflux in all headache groups suggests that thereduced end-exercise acidification was due to a reduction of glycolytic flux in migraine patients. The maximum rate of mitochondrial ATP production (Q(max)), calculated from the rate of post-exercise PCr recovery and the end-exercise [ADP], was low in cluster headache patients as well as in migraine patients except MwoA. In migraine the degree of the mitochondrial impairment, that apparently is associated with a reduced glycolytic flux, is related to the severity of the clinical phenotype. (C) 1997 Elsevier Science B.V.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 20/01/20 alle ore 16:06:33