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Titolo:
EXPERIMENTAL MITOCHONDRIAL MYOPATHY INDUCED BY CHRONIC INTOXICATION BY SENNA-OCCIDENTALIS SEEDS
Autore:
CALORE EE; CAVALIERE MJ; HARAGUCHI M; GORNIAK SL; DAGLI MLZ; RASPANTINI PC; CALORE NMP;
Indirizzi:
EMILIO RIBAS INST,SECT PATHOL,AV DR ARNAIDO 165 BR-01246001 SAO PAULOBRAZIL UNIV SAO PAULO,FAC MED,DEPT PATHOL,LAB MOL PATHOL SAO PAULO BRAZIL ADOLFO LUTZ INST,SECT PATHOL SAO PAULO BRAZIL INST BIOL,DIV ANIM BIOL,PHARMACOL SECT SAO PAULO BRAZIL UNIV SAO PAULO,FAC VET MED & ZOOTECHNY,DEPT PATHOL SAO PAULO BRAZIL
Titolo Testata:
Journal of the neurological sciences
fascicolo: 1, volume: 146, anno: 1997,
pagine: 1 - 6
SICI:
0022-510X(1997)146:1<1:EMMIBC>2.0.ZU;2-F
Fonte:
ISI
Lingua:
ENG
Soggetto:
CASSIA-OCCIDENTALIS; LEG CAES; POISONED RABBITS; CATTLE;
Keywords:
MITOCHONDRIA; MITOCHONDRIAL MYOPATHY; SENNA OCCIDENTALIS; TOXIC PLANTS; MUSCLE DISEASES; METABOLIC MYOPATHIES; TOXIC MYOPATHIES;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
27
Recensione:
Indirizzi per estratti:
Citazione:
E.E. Calore et al., "EXPERIMENTAL MITOCHONDRIAL MYOPATHY INDUCED BY CHRONIC INTOXICATION BY SENNA-OCCIDENTALIS SEEDS", Journal of the neurological sciences, 146(1), 1997, pp. 1-6

Abstract

Histochemical and electron microscopic studies of biceps femoris, pectoralis major and rectus femoris of chronically treated birds with seeds of the poisonous plant Senna occidentalis (0.2% external/internal tegment), were performed. The muscles had similar features of human mitochondrial myopathy as ragged-red fibers, cytochrome-oxidase negative fibers, and weak activity of the oxidative enzymes, Fibers with lipid storage were also present. Acid phosphatase activity in rare muscle fibers was also detected, and represents probably a secondary degenerative process, By electron microscopy, enlarged mitochondria with disrupted or excessively branched cristae were seen. The present study presents a new experimental model of mitochondrial myopathy that may be useful for the best knowledge of this group of diseases and for experimental trials of drugs that could reverse the mitochondrial impairment in the mitochondrial myopathies. (C) 1997 Elsevier Science B.V.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 20/02/20 alle ore 03:11:02