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Titolo:
TREATMENT OF SCHIZOPHRENIA - A CLINICAL AND PRECLINICAL EVALUATION OFNEUROLEPTIC DRUGS
Autore:
ELLENBROEK BA;
Indirizzi:
CATHOLIC UNIV NIJMEGEN,DEPT PSYCHOPHARMACOL & NEUROPHARMACOL,POB 91016500 HB NIJMEGEN NETHERLANDS
Titolo Testata:
Pharmacology & therapeutics
fascicolo: 1, volume: 57, anno: 1993,
pagine: 1 - 78
SICI:
0163-7258(1993)57:1<1:TOS-AC>2.0.ZU;2-I
Fonte:
ISI
Lingua:
ENG
Soggetto:
CLOZAPINE-INDUCED AGRANULOCYTOSIS; ABNORMAL INVOLUNTARY MOVEMENTS; SYMPTOM-FREE SCHIZOPHRENICS; INDUCED EXTRAPYRAMIDAL SYMPTOMS; CONDITIONED-AVOIDANCE-RESPONSE; AMPHETAMINE-INDUCED STEREOTYPY; STRIATAL DOPAMINE METABOLISM; POSITRON EMISSION TOMOGRAPHY; CHRONIC PSYCHOTIC-PATIENTS; INDUCED LOCOMOTOR ACTIVITY;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
650
Recensione:
Indirizzi per estratti:
Citazione:
B.A. Ellenbroek, "TREATMENT OF SCHIZOPHRENIA - A CLINICAL AND PRECLINICAL EVALUATION OFNEUROLEPTIC DRUGS", Pharmacology & therapeutics, 57(1), 1993, pp. 1-78

Abstract

Forty years after the first clinical report on the effectiveness of chlorpromazine in psychiatric patients, neuroleptic drugs are still themost widely used drugs in the treatment of schizophrenia. Indeed, there are no other drugs which have proven to be as effective in the treatment of this severe psychiatric disorder. Yet, there are still many unresolved problems relating to neuroleptic drugs. The present review gives a comprehensive overview of our knowledge (and our lack of knowledge) with respect to the clinical and preclinical effects of neuroleptic drugs and tries to integrate this knowledge in order to identify the neuronal mechanisms underlying the therapeutic and side effects of neuroleptic drugs.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 26/01/20 alle ore 00:33:57