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Titolo:
INTERLEUKIN-9 POTENTIATES THE INTERLEUKIN-4-INDUCED IGE AND IGG1 RELEASE FROM MURINE B-LYMPHOCYTES
Autore:
PETITFRERE C; DUGAS B; BRAQUET P; MENCIAHUERTA JM;
Indirizzi:
INST HENRI BEAUFOUR,DEPT IMMUNOL,1 AVE TROPIGUE F-91952 LES LILIS FRANCE INST HENRI BEAUFOUR,DEPT IMMUNOL,1 AVE TROPIGUE F-91952 LES LILIS FRANCE
Titolo Testata:
Immunology
fascicolo: 1, volume: 79, anno: 1993,
pagine: 146 - 151
SICI:
0019-2805(1993)79:1<146:IPTIIA>2.0.ZU;2-V
Fonte:
ISI
Lingua:
ENG
Soggetto:
GROWTH-ENHANCING ACTIVITY; ANTIBODY-SECRETING CELLS; T-CELL; ACTIVITY MEA; LIPOPOLYSACCHARIDE; EXPRESSION; RESPONSES; RECEPTORS; EPSILON; LINES;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
23
Recensione:
Indirizzi per estratti:
Citazione:
C. Petitfrere et al., "INTERLEUKIN-9 POTENTIATES THE INTERLEUKIN-4-INDUCED IGE AND IGG1 RELEASE FROM MURINE B-LYMPHOCYTES", Immunology, 79(1), 1993, pp. 146-151

Abstract

Interleukin-9 (IL-9) is a mouse T-cell-derived cytokine that supportsthe growth of mucosal type mast cells suggesting its role in the regulation of type I hypersensitivity reactions. Therefore the possible effect of IL-9 on the in vitro regulation of IL-4-induced IgE and IgG1 releases in the mouse was investigated. In this report, we present evidence that IL-9 potentiated IL-4-induced IgE and IgG1 releases from lipopolysaccharide (LPS)-primed murine B lymphocytes, whereas IL-9 alone was ineffective. The potentiating effect of IL-9 is specific for IgE and IgG1 since no effect on IgM production was observed. This potentiating effect was neither related to an enhanced cell viability, nor to an alteration of the IL-4-induced expression of class II antigens by murine B cells. Besides the fact that IL-9 increased the number of IgG1-secreting cells, this cytokine might also enhance immunoglobulin release on a cell basis. Taken together, these data suggest that IL-9 playsan in vitro regulatory role in antibody synthesis, probably via a direct action on murine B lymphocytes.

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Documento generato il 20/09/20 alle ore 10:43:21