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Titolo:
A MOLECULAR VARIANT OF ANGIOTENSINOGEN ASSOCIATED WITH PREECLAMPSIA
Autore:
WARD K; HATA A; JEUNEMAITRE X; HELIN C; NELSON L; NAMIKAWA C; FARRINGTON PF; OGASAWARA M; SUZUMORI K; TOMODA S; BERREBI S; SASAKI M; CORVOL P; LIFTON RP; LALOUEL JM;
Indirizzi:
UNIV UTAH,SCH MED,DEPT OBSTET & GYNECOL SALT LAKE CITY UT 84132 NAGOYA CITY UNIV,SCH MED,DEPT BIOCHEM,MIZUHO KU NAGOYA AICHI 467 JAPAN UNIV UTAH,SCH MED,HOWARD HUGHES MED INST SALT LAKE CITY UT 84112 UNIV UTAH,SCH MED,ECCLES INST HUMAN GENET,DEPT HUMAN GENET SALT LAKE CITY UT 84112 HOP BROUSSAIS,DEPT HYPERTENS F-75674 PARIS 14 FRANCE NAGOYA CITY UNIV,SCH MED,DEPT OBSTET & GYNECOL,MIZUHO KU NAGOYA AICHI467 JAPAN OSAKA CITY UNIV,SCH MED,DEPT OBSTET & GYNECOL OSAKA 545 JAPAN BRIGHAM & WOMENS HOSP,DIV ENDOCRINE HYPERTENS BOSTON MA 02115 HARVARD UNIV,SCH MED BOSTON MA 02115
Titolo Testata:
Nature genetics
fascicolo: 1, volume: 4, anno: 1993,
pagine: 59 - 61
SICI:
1061-4036(1993)4:1<59:AMVOAA>2.0.ZU;2-G
Fonte:
ISI
Lingua:
ENG
Soggetto:
PREGNANCY; GENE; SUSCEPTIBILITY; ECLAMPSIA; WOMEN;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
23
Recensione:
Indirizzi per estratti:
Citazione:
K. Ward et al., "A MOLECULAR VARIANT OF ANGIOTENSINOGEN ASSOCIATED WITH PREECLAMPSIA", Nature genetics, 4(1), 1993, pp. 59-61

Abstract

Pregnancy-induced hypertension (PIH) is a heterogeneous disorder which complicates 5-7% of all pregnancies and remains a leading cause of maternal, fetal and neonatal morbidity and mortality. Severe preeclampsia is the most distinctive and life-threatening form; a multi-system disorder more common in first pregnancies, it is characterized by high blood pressure and proteinuria. In a series of Caucasian women with pregnancy-induced hypertension, we have observed a significant association of preeclampsia with a molecular variant of angiotensinogen, T235, found previously to be associated with essential hypertension. This finding is corroborated in a sample ascertained in Japan. Together, these observations support a new pathophysiological interpretation of preeclampsia and of its relation to some forms of essential hypertension.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 20/01/21 alle ore 15:55:07