Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
DECREASED FIBRONECTIN RECEPTOR EXPRESSION RESULTS IN INCREASED TUMORIGENICITY OF COLONIC EPITHELIAL-CELLS
Autore:
STALLMACH A; VONLAMPE B; ORZECHOWSKI HD; RIECKEN EO;
Indirizzi:
FREE UNIV BERLIN,KLINIKUM STEGLITZ,MED KLIN & POLIKLIN SCHWERPUNKT GASTROENTEROL W-1000 BERLIN 45 GERMANY
Titolo Testata:
Medizinische Klinik
fascicolo: 4, volume: 88, anno: 1993,
pagine: 175 - 180
SICI:
0723-5003(1993)88:4<175:DFRERI>2.0.ZU;2-V
Fonte:
ISI
Lingua:
GER
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
NO
Recensione:
Indirizzi per estratti:
Citazione:
A. Stallmach et al., "DECREASED FIBRONECTIN RECEPTOR EXPRESSION RESULTS IN INCREASED TUMORIGENICITY OF COLONIC EPITHELIAL-CELLS", Medizinische Klinik, 88(4), 1993, pp. 175-180

Abstract

Following malignant transformation, epithelial cells of colorectal carcinomas unlike normal colonic epithelial cells do not any longer express the classical alpha5beta1 fibronectin receptor. We speculated thatthe loss of alpha5beta1 expression may facilitate the tumorigenicity of transformed colonic cells. To examine this hypothesis, we established subclones of the human colon adenocarcinoma cell line HT29 which differ in their fibronectin receptor expression and tested their tumorigenicity in nude mice. Our data indicate that the capacity to form tumors in nude mice after subcutaneous injection was significantly lower for alpha5beta1-positive than for alpha5beta1-negative cell clones. In addition, tumors from clones expressing to detectable levels of alpha5beta1 grew rapidly, while tumors expressing elevated levels of fibronectin receptor grew slowly. Deposition of fibronectin in tumor-surrounding stroma was increased in tumors derived from alpha5beta1-Positive cells compared to tumors derived from alpha5beta1-negative cells. Our results indicate that a reduction of the alpha5beta1-mediated interaction of epithelial cells with the extracellular matrix may be responsible for increased tumorigenicity of malignant transformed cells in colorectal carcinomas.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 01/12/20 alle ore 10:48:37