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Titolo:
CARDIOVASCULAR CHANGE AND HYPOTHALAMIC NOREPINEPHRINE RELEASE IN RESPONSE TO ENVIRONMENTAL-STRESS
Autore:
NAKATA T; BERARD W; KOGOSOV E; ALEXANDER N;
Indirizzi:
UNIV SO CALIF,SCH MED,DEPT MED,HMR 801,2011 ZONAL AVE LOS ANGELES CA 90033 UNIV SO CALIF,SCH MED,DEPT MED,HMR 801,2011 ZONAL AVE LOS ANGELES CA 90033 UNIV SO CALIF,SCH MED,DEPT ANAT & CELL BIOL LOS ANGELES CA 90033
Titolo Testata:
The American journal of physiology
fascicolo: 4, volume: 264, anno: 1993,
parte:, 2
pagine: 784 - 789
SICI:
0002-9513(1993)264:4<784:CCAHNR>2.0.ZU;2-9
Fonte:
ISI
Lingua:
ENG
Soggetto:
SPONTANEOUSLY HYPERTENSIVE RATS; PARAVENTRICULAR NUCLEUS; NORADRENALINE RELEASE; ETHER STRESS; ELECTRICAL-STIMULATION; POSTERIOR HYPOTHALAMUS; AWAKE RATS; BRAIN; MICRODIALYSIS; SECRETION;
Keywords:
INVIVO MICRODIALYSIS; PARAVENTRICULAR HYPOTHALAMIC NUCLEUS; POSTERIOR HYPOTHALAMIC NUCLEUS; NOREPINEPHRINE; BLOOD PRESSURE; PLASMA CATECHOLAMINES AND CORTICOSTERONE; URETHANE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
34
Recensione:
Indirizzi per estratti:
Citazione:
T. Nakata et al., "CARDIOVASCULAR CHANGE AND HYPOTHALAMIC NOREPINEPHRINE RELEASE IN RESPONSE TO ENVIRONMENTAL-STRESS", The American journal of physiology, 264(4), 1993, pp. 784-789

Abstract

The major objective of this study was to compare the magnitude and duration of cardiovascular (CV) responses to acute environmental stresses with the associated patterns of noradrenergic activity in the paraventricular nucleus (PVN) and posterior nucleus (PH) of the hypothalamus. Simultaneous microdialysis samples of extracellular norepinephrine (NE) were collected at 5-min intervals from PVN and PH and the CV responses were recorded before, during, and for 15 min after acute shaker (cage oscillation) stress or inhalation of ether vapor in freely movingrats. Five minutes of shaker stress, 60 and 150 cycles/min, elicited pressor responses coupled with increases in dialysate NE from both PVNand PH in a frequency-dependent manner. Tachycardia occurred at 150 but not 60 cycles/min. Ten minutes after 60 cycles/min and 15 min after150 cycles/min, NE efflux in PH was still increased, whereas in PVN it returned to control as had arterial pressure and heart rate. Ether vapor elicited a transient CV response but a continuing efflux of NE inPH and PVN. Urethan anesthesia raised baseline values of dialysate NEin PH and PVN but significantly attenuated cardiovascular and dialysate NE responses to shaker stress. We conclude that acute environmentalstress simultaneously elicits CV responses and the efflux of NE from PVN and PH but, during or after stress, CV values may return to control levels while NE efflux remains elevated in PVN and/or PH.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 28/09/20 alle ore 13:33:55