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Titolo:
EXERCISE-INDUCED ASTHMA
Autore:
MAHLER DA;
Indirizzi:
DARTMOUTH COLL,HITCHCOCK MED CTR,PULM & CRIT CARE MED SECT,3-D,1 MED CTR DR HANOVER NH 03756
Titolo Testata:
Medicine and science in sports and exercise
fascicolo: 5, volume: 25, anno: 1993,
pagine: 554 - 561
SICI:
0195-9131(1993)25:5<554:EA>2.0.ZU;2-I
Fonte:
ISI
Lingua:
ENG
Soggetto:
NEUTROPHIL CHEMOTACTIC ACTIVITY; INDUCED BRONCHOCONSTRICTION; BRONCHIAL HYPERREACTIVITY; CROMOLYN SODIUM; WATER-LOSS; AIR-FLOW; WARM-UP; HISTAMINE; CHALLENGE; DURATION;
Keywords:
REFRACTORY PERIOD; RESPIRATORY HEAT EXCHANGE; LATE PHASE RESPONSE; BRONCHOPROVOCATION TESTING; EXERCISE CHALLENGE TEST; BRONCHODILATORY THERAPY;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
63
Recensione:
Indirizzi per estratti:
Citazione:
D.A. Mahler, "EXERCISE-INDUCED ASTHMA", Medicine and science in sports and exercise, 25(5), 1993, pp. 554-561

Abstract

Bronchoconstriction associated with exercise can occur in nearly all individuals with asthma and in 35-40% of those with allergic rhinitis/hay fever symptoms. This represents approximately 12-15% of the population. Exercise-induced asthma (EIA) is a clinical syndrome characterized by transient airflow obstruction typically 5-15 min after cessationof physical exertion. Symptoms may include chest tightness, breathlessness. coughing, and/or wheezing. Some individuals may experience delayed bronchoconstriction (late phase response) 6-10 h after completing exercise. Approximately 40-50% of those with asthma exhibit a ''refractory period'', i.e., diminished bronchoconstriction to exercise performed within 2 h. The pathophysiology of EIA is related to thermal events within the intrathoracic airways. Alterations in the temperature of the airways and/or osmolarity in the epithelial lining fluid cause release of mediators in the airways and the development of bronchoconstriction. Although EIA can be strongly suspected by an appropriate history, pulmonary function testing is necessary to make a specific diagnosis. Measurement of lung function is an important first diagnostic test. If there is no evidence of airflow obstruction at rest, then either bronchoprovocation testing or exercise challenge testing is indicated. Nonpharmacologic therapy includes ''warm-up'' exercise prior to training or competition to induce a ''refractory period'' and to prevent/reduce bronchoconstriction. An inhaled beta2-adrenergic agonist, e.g., albuterol, is usually effective for preventing/treating EIA. Cromolyn sodium is an alternative class of medication that inhibits both the early and late phase responses. Other bronchodilator agents are available if combination therapy with an inhaled beta2-adrenergic agonist and cromolyn sodium is not effective. Health care providers should encourageindividuals with asthma to be physically active and should provide education about asthma management as related to EIA.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 09/07/20 alle ore 12:59:16