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Titolo:
ANTIDEPRESSANT-LIKE EFFECTS OF A PARTIAL AGONIST AT STRYCHNINE-INSENSITIVE GLYCINE RECEPTORS AND A COMPETITIVE NMDA RECEPTOR ANTAGONIST
Autore:
PRZEGALINSKI E; TATARCZYNSKA E; DERENWESOLEK A; CHOJNACKAWOJCIK E;
Indirizzi:
POLISH ACAD SCI,INST PHARMACOL,12 SMETNA ST PL-3134 KRAKOW POLAND
Titolo Testata:
Neuropharmacology
fascicolo: 1, volume: 36, anno: 1997,
pagine: 31 - 37
SICI:
0028-3908(1997)36:1<31:AEOAPA>2.0.ZU;2-D
Fonte:
ISI
Lingua:
ENG
Soggetto:
PHENCYCLIDINE-LIKE; BINDING-SITES; 1-AMINOCYCLOPROPANECARBOXYLIC ACID; EXHIBIT ANTIDEPRESSANT; FUNCTIONAL ANTAGONISTS; RHESUS-MONKEYS; RAT-BRAIN; MK-801; DEPRESSION; COMPLEX;
Keywords:
1-AMINOCYCLOPROPANECARBOXYLIC ACID; CGP 37849; FORCED SWIMMING TEST; PERIPHERAL ADMINISTRATION; INTRAHIPPOCAMPAL INJECTION; RATS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
49
Recensione:
Indirizzi per estratti:
Citazione:
E. Przegalinski et al., "ANTIDEPRESSANT-LIKE EFFECTS OF A PARTIAL AGONIST AT STRYCHNINE-INSENSITIVE GLYCINE RECEPTORS AND A COMPETITIVE NMDA RECEPTOR ANTAGONIST", Neuropharmacology, 36(1), 1997, pp. 31-37

Abstract

Using the forced swimming test in rats (Porsolt test), we examined the antidepressant-like activity of 1-aminocyclopropanecarboxylic acid (ACPC), a partial agonist at strychnine-insensitive glycine receptors associated with the N-methyl-D-aspartate (NMDA) receptor complex, and of DL-(E)-2-amino-4-methyl-5-phosphono-3-pentenoic acid (CGP 37849), a competitive NMDA receptor antagonist, after their intraperitoneal (i.p.) and intrahippocampal (i.hp.) administration. ACPC (200-400 mg/kg) and CGP 37849 (0.625-5 mg/kg), administered i.p., produced a dose-dependent and significant reduction of the immobility time in the forced swimming test. A similar effect was also observed after i.hp. administration of ACPC (10 and 30 mu g) and CGP 37849 (0.03 and 0.1 mu g). Imipramine, used as a reference drug, significantly shortened the immobility time after both i.p. (30 and 40 mg/kg) and i.hp. (0.1 and 0.3 mu g) administration. The compounds studied, administered in doses effectivein the forced swimming test, did not change the exploratory activity of the rats, evaluated by an open field test. The present results indicate that, like imipramine, ACPC and CGP 37849 exhibit an antidepressant-like activity in the forced swimming test in rats; moreover, they seem to show that the hippocampus may be one of the neuroanatomical sites involved in this effect. (C) 1997 Elsevier Science Ltd.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 30/11/20 alle ore 03:36:39