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Titolo:
REARRANGEMENT AND DIVERSITY OF T-CELL RECEPTOR BETA-CHAIN GENES IN THYMOCYTES - A CRITICAL ROLE FOR THE BETA-CHAIN IN DEVELOPMENT
Autore:
MALLICK CA; DUDLEY EC; VINEY JL; OWEN MJ; HAYDAY AC;
Indirizzi:
YALE UNIV,DEPT BIOL NEW HAVEN CT 06511 IMPERIAL CANC RES FUND LONDON WC2A 3PX ENGLAND
Titolo Testata:
Cell
fascicolo: 3, volume: 73, anno: 1993,
pagine: 513 - 519
SICI:
0092-8674(1993)73:3<513:RADOTR>2.0.ZU;2-T
Fonte:
ISI
Lingua:
ENG
Soggetto:
TRANSGENIC MICE; LYMPHOCYTES-B; PRE-B; EXPRESSION; DNA; ORGANIZATION; REPERTOIRE; SEGMENTS; LAMBDA-5; THYMUS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
34
Recensione:
Indirizzi per estratti:
Citazione:
C.A. Mallick et al., "REARRANGEMENT AND DIVERSITY OF T-CELL RECEPTOR BETA-CHAIN GENES IN THYMOCYTES - A CRITICAL ROLE FOR THE BETA-CHAIN IN DEVELOPMENT", Cell, 73(3), 1993, pp. 513-519

Abstract

Thymocytes from mice congenitally deficient for TCR alpha chain synthesis were examined for the status of their TCR beta chain genes, by DNA sequencing and by a novel technique that analyzes populations of gene rearrangements. TCR beta chain genes were predominantly productivelyrearranged, in contrast with the statistical prediction for a quasi-random rearrangement process. Therefore, productive TCR beta chain generearrangement appears to be a critical step in thymocyte maturation, independent of TCR alpha chain expression. Moreover, the beta chain gene rearrangements in TCRalpha-/- mice are typical of those found in the thymus and periphery of normal mice. Thus, the extent of junctional diversity is a property of TCR genes that is imposed prior to selection on the mature alphabeta TCR.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 26/09/20 alle ore 18:21:11