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Titolo:
ENHANCED PHOSPHORYLATION OF THE POSTSYNAPTIC PROTEIN-KINASE-C SUBSTRATE RC3 NEUROGRANIN DURING LONG-TERM POTENTIATION/
Autore:
CHEN SJ; SWEATT JD; KLANN E;
Indirizzi:
UNIV PITTSBURGH,DEPT NEUROSCI,446 CRAWFORD HALL PITTSBURGH PA 15260 BAYLOR COLL MED,DIV NEUROSCI HOUSTON TX 77030
Titolo Testata:
Brain research
fascicolo: 2, volume: 749, anno: 1997,
pagine: 181 - 187
SICI:
0006-8993(1997)749:2<181:EPOTPP>2.0.ZU;2-D
Fonte:
ISI
Lingua:
ENG
Soggetto:
CALMODULIN-BINDING PROTEIN; IMMUNOCYTOCHEMICAL LOCALIZATION; BOVINE BRAIN; GROWTH CONES; B-50 GAP-43; NEUROGRANIN; MAINTENANCE; PURIFICATION; ACTIVATION; TISSUE;
Keywords:
POSTSYNAPTIC PROTEIN; PROTEIN KINASE C SUBSTRATE; SYNAPTIC PLASTICITY; HIPPOCAMPUS; LEARNING AND MEMORY; CALMODULIN;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
33
Recensione:
Indirizzi per estratti:
Citazione:
S.J. Chen et al., "ENHANCED PHOSPHORYLATION OF THE POSTSYNAPTIC PROTEIN-KINASE-C SUBSTRATE RC3 NEUROGRANIN DURING LONG-TERM POTENTIATION/", Brain research, 749(2), 1997, pp. 181-187

Abstract

Long-term potentiation (LTP) is a sustained strengthening of synapticconnections that occurs in the mammalian hippocampus, and is a cellular mechanism likely to contribute to memory formation. One question ofcurrent interest is whether the biochemical mechanisms responsible for the maintenance of LTP have a presynaptic or postsynaptic locus. We have determined that the phosphorylation of the postsynaptic protein kinase (PKC) substrate RC3/neurogranin is increased in the maintenance phase of LTP, and that the induction of this effect is dependent on activation of the N-methyl-D-aspartate (NMDA) subtype of glutamate receptors. The sustained increase in RC3/neurogranin phosphorylation requires ongoing protein kinase activity, as application of the protein kinase inhibitor H-7 after LTP induction can reverse the increased RC3/neurogranin phosphorylation. Overall, these data are evidence for postsynaptic biochemical changes in the maintenance of LTP. They also implicate RC3/neurogranin as a downstream effector of PKC activity in LTP that could contribute to physiologic expression of LTP.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 08/04/20 alle ore 12:18:27