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Titolo:
GENETIC AND MOLECULAR CHARACTERIZATION OF A NOTCH MUTATION IN ITS DELTA-BINDING AND SERRATE-BINDING DOMAIN IN DROSOPHILA
Autore:
DECELIS JF; BARRIO R; DELARCO A; GARCIABELLIDO A;
Indirizzi:
UNIV AUTONOMA MADRID,CTR BIOL MOLEC SEVERO OCHOA,CANTOBLANCO E-28049 MADRID SPAIN UNIV AUTONOMA MADRID,CTR BIOL MOLEC SEVERO OCHOA,CANTOBLANCO E-28049 MADRID SPAIN
Titolo Testata:
Proceedings of the National Academy of Sciences of the United Statesof America
fascicolo: 9, volume: 90, anno: 1993,
pagine: 4037 - 4041
SICI:
0027-8424(1993)90:9<4037:GAMCOA>2.0.ZU;2-B
Fonte:
ISI
Lingua:
ENG
Soggetto:
EPIDERMAL GROWTH-FACTOR; EGF-LIKE REPEATS; TRANSMEMBRANE PROTEIN; EARLY NEUROGENESIS; NEGATIVE COMPLEMENTATION; MELANOGASTER; LOCUS; ENCODES; DIFFERENTIATION; EXPRESSION;
Keywords:
PROTEIN PROTEIN INTERACTIONS; RECEPTOR LIGAND COMPLEXES; CELL SIGNALING;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
52
Recensione:
Indirizzi per estratti:
Citazione:
J.F. Decelis et al., "GENETIC AND MOLECULAR CHARACTERIZATION OF A NOTCH MUTATION IN ITS DELTA-BINDING AND SERRATE-BINDING DOMAIN IN DROSOPHILA", Proceedings of the National Academy of Sciences of the United Statesof America, 90(9), 1993, pp. 4037-4041

Abstract

The Drosophila Notch gene product is a transmembrane protein that functions as a receptor of intercellular signals in several Drosophila developmental processes. Two other transmembrane proteins, encoded by the genes Delta and Serrate, genetically and molecularly behave as Notchligands. All these proteins share the presence of epidermal growth factor (EGF)-like repeats in their extracellular domain. The Notch protein has 36 EGF-like repeats, 2 of which, numbers 11 and 12, are required for the interaction with the Delta and Serrate ligands. We have isolated and molecularly characterized a Notch mutation in its Delta- and Serrate-binding domain that behaves genetically as both a Notch antimorphic and a loss-of-function mutation. This mutation, N(M1), carries aGlu --> Val substitution in the Notch EGF repeat 12. The N(M1) alleleinteracts with other Notch alleles such as Abruptex and split and with mutations in the Notch-ligand genes Delta and Serrate. The basis forthe genetic antimorphism of N(M1) seems to reside in the titration ofNotch wild-type products into N(M1)/N+ nonfunctional dimers and/or the titration of Delta products into nonfunctional ligand-receptor complexes.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 14/08/20 alle ore 17:06:02