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Titolo:
NEUTRALIZING ANTIBODY-RESPONSE DURING HUMAN-IMMUNODEFICIENCY-VIRUS TYPE-1 INFECTION - TYPE AND GROUP SPECIFICITY AND VIRAL ESCAPE
Autore:
ARENDRUP M; SONNERBORG A; SVENNERHOLM B; AKERBLOM L; NIELSEN C; CLAUSEN H; OLOFSSON S; NIELSEN JO; HANSEN JES;
Indirizzi:
UNIV COPENHAGEN,HVIDOVRE HOSP,DEPT INFECT DIS 144 DK-2650 HVIDOVRE DENMARK CENT MICROBIOL LAB STOCKHOLM SWEDEN NATL VET INST,CTR BIOMED,DEPT VIROL UPPSALA SWEDEN ROYAL DENT COLL,PANUM INST,DEPT ORAL DIAGNOST DK-2100 COPENHAGEN DENMARK GOTHENBURG UNIV,DEPT CLIN VIROL S-41124 GOTHENBURG SWEDEN STATENS SERUM INST,DEPT VIROL DK-2300 COPENHAGEN DENMARK
Titolo Testata:
Journal of General Virology
, volume: 74, anno: 1993,
parte:, 5
pagine: 855 - 863
SICI:
0022-1317(1993)74:<855:NADHT>2.0.ZU;2-X
Fonte:
ISI
Lingua:
ENG
Soggetto:
MONOCLONAL-ANTIBODIES; ENVELOPE GLYCOPROTEIN-GP120; HIV-1; AIDS; GLYCOSYLATION; INHIBITION; GENERATION; INVITRO; VARIANT; CELLS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
31
Recensione:
Indirizzi per estratti:
Citazione:
M. Arendrup et al., "NEUTRALIZING ANTIBODY-RESPONSE DURING HUMAN-IMMUNODEFICIENCY-VIRUS TYPE-1 INFECTION - TYPE AND GROUP SPECIFICITY AND VIRAL ESCAPE", Journal of General Virology, 74, 1993, pp. 855-863

Abstract

The paradox that group-specific neutralizing antibodies (NA) exist inthe majority of human immunodeficiency virus type 1 (HIV-1)-infected patients, whereas the NA response against autologous HIV-1 virus isolates is highly type-specific, motivated us to study the type- and group-specific NA responses generated upon presentation of escape virus, and the viral epitopes involved in the escape. Patients with demonstrable escape virus all developed group-specific NA, which were detectable after a delay and disappeared prior to disease development. The sera tested inhibited the binding of recombinant soluble gp120IIIB to cell-associated CD4, but group-specific virus neutralization required binding of NA to HIV-I prior to viral attachment to target cells. Consecutive escape virus isolates were tested for sensitivity to neutralization by heterologous sera. Only minor differences were demonstrated, suggesting that the majority of the change in neutralization sensitivity is driven by the selective pressure of type-specific NA. Furthermore, no differences were observed in sensitivity to neutralization by anti-carbohydrate neutralizing monoclonal antibodies or the lectin concanavalin A, indicating a conserved nature of certain carbohydrate neutralization epitopes during escape. Finally the V3 sequence of three sets of consecutive virus isolates were analysed revealing amino acid mutationsin V3 sequences of all escape virus isolates. The biological significance of these variations was confirmed further by the demonstration ofchanges in sensitivity to neutralization by anti-V3 monoclonal antibodies. These results strongly suggest a participation of the NA response against the V3 loop in the immunoselection of escape virus.

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Documento generato il 02/12/20 alle ore 15:00:34