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Titolo:
WHY ARE ENDOCRINE PITUITARY-CELLS EXCITABLE
Autore:
MOLLARD P; SCHLEGEL W;
Indirizzi:
CCIPE,INSERM U401,141 RUE CARDONILLE F-34094 MONTPELLIER 05 FRANCE UNIV GENEVA,DEPT MED,FDN RECH MED CH-1211 GENEVA SWITZERLAND
Titolo Testata:
Trends in endocrinology and metabolism
fascicolo: 10, volume: 7, anno: 1996,
pagine: 361 - 365
SICI:
1043-2760(1996)7:10<361:WAEPE>2.0.ZU;2-Q
Fonte:
ISI
Lingua:
ENG
Soggetto:
THYROTROPIN-RELEASING-HORMONE; ACTIVATED CALCIUM CHANNELS; DEPENDENT CA2+ CHANNELS; RAT LACTOTROPH CELLS; CYTOSOLIC CALCIUM; ACTION-POTENTIALS; TUMOR CELLS; K+ CURRENT; DOPAMINE; CA-2+;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
45
Recensione:
Indirizzi per estratti:
Citazione:
P. Mollard e W. Schlegel, "WHY ARE ENDOCRINE PITUITARY-CELLS EXCITABLE", Trends in endocrinology and metabolism, 7(10), 1996, pp. 361-365

Abstract

Since 1975, endocrine pituitary cells have been known to be excisableneuronlike cells. Using powerful single-cell approaches, in particular the patch clamp electrophysiological recording technique and the monitoring of Ca2+ with fluorescent probes solid evidence has been provided in the last 10 years that intracellular Ca2+ signals are produced by stimulators and inhibitors of secretion via the modulation of actionpotentials in isolated pituitary cells. As cytosolic Ca2+ changes avethought to control numerous cellular functions (for example, secretion protein synthesis, gene expression and proliferation) over a long time scale-milliseconds to hours-it is now time to address the longstanding question of what functions would be physiologically controlled by electrical excitability in intact pituitary tissue. (C) 1996, ElsevierScience Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 27/01/20 alle ore 16:55:24