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Titolo:
AMBULATORY BLOOD-PRESSURE AND LEFT-VENTRICULAR MASS IN CYCLOSPORINE-TREATED AND NON-CYCLOSPORINE-TREATED RENAL-TRANSPLANT RECIPIENTS
Autore:
LIPKIN GW; TUCKER B; GILES M; RAINE AEG;
Indirizzi:
ST BARTHOLOMEWS HOSP,DEPT NEPHROL,RENAL UNIT LONDON EC1A 7BE ENGLAND ST BARTHOLOMEWS HOSP,DEPT NEPHROL,RENAL UNIT LONDON EC1A 7BE ENGLAND
Titolo Testata:
Journal of hypertension
fascicolo: 4, volume: 11, anno: 1993,
pagine: 439 - 442
SICI:
0263-6352(1993)11:4<439:ABALMI>2.0.ZU;2-Y
Fonte:
ISI
Lingua:
ENG
Soggetto:
M-MODE; HYPERTROPHY; HEMODIALYSIS; DISEASE; ANEMIA;
Keywords:
RENAL TRANSPLANT; AMBULATORY BLOOD PRESSURE; LEFT VENTRICULAR MASS; MORTALITY; CYCLOSPORINE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
21
Recensione:
Indirizzi per estratti:
Citazione:
G.W. Lipkin et al., "AMBULATORY BLOOD-PRESSURE AND LEFT-VENTRICULAR MASS IN CYCLOSPORINE-TREATED AND NON-CYCLOSPORINE-TREATED RENAL-TRANSPLANT RECIPIENTS", Journal of hypertension, 11(4), 1993, pp. 439-442

Abstract

Objectives: First, to determine the relationship between left ventricular mass (LVM) and clinic and 24-h ambulatory blood pressure parameters in normotensive renal transplant recipients. Secondly, to assess the influence of immunosuppression protocol on diurnal blood pressure and target-organ response. Design: Measurement of supine clinic blood pressure, non-invasive 24-h ambulatory blood pressure and echocardiographically determined LVM. Patients: Twenty-eight stable, normotensive renal transplant recipients taking no antihypertensive therapy (16 cyclosporin-treated and 12 non-cyclosporin-treated). Setting: Community-based ambulatory patients reviewed in tertiary referral centre. Main outcome measures: Clinic blood pressure, mean 24-h, daytime and night-timeambulatory blood pressure and LVM. Results: Mean 24-h blood pressure exceeded that recorded in the clinic. Twenty-five per cent of patientshad left ventricular hypertrophy despite the absence of hypertension,and this was more common in cyclosporin-treated than in non-cyclosporin-treated patients. Mean daytime systolic blood pressure was the bestpredictor of LVM, being superior to clinic blood pressure and any diastolic blood pressure parameter. An attenuated nocturnal blood pressure fall ('non-dipper' pattern) was common, especially in those patientstreated with cyclosporin, and was associated with higher LVM. Conclusion: In normotensive renal transplant recipients, a group at risk of cardiovascular disease, 24-h ambulatory blood pressure is closely related to the development of left ventricular hypertrophy, and may prove useful in optimizing treatment strategies to reduce cardiovascular morbidity.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 25/11/20 alle ore 04:45:04