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Titolo:
CHRONIC INHIBITION OF ENDOPEPTIDASE 24.11 IN ESSENTIAL-HYPERTENSION -EVIDENCE FOR ENHANCED ATRIAL-NATRIURETIC-PEPTIDE AND ANGIOTENSIN-II
Autore:
RICHARDS AM; WITTERT GA; CROZIER IG; ESPINER EA; YANDLE TG; IKRAM H; FRAMPTON C;
Indirizzi:
PRINCESS MARGARET HOSP,DEPT CARDIOL,CAS CHRISTCHURCH 2 NEW ZEALAND PRINCESS MARGARET HOSP,DEPT ENDOCRINOL CHRISTCHURCH 2 NEW ZEALAND
Titolo Testata:
Journal of hypertension
fascicolo: 4, volume: 11, anno: 1993,
pagine: 407 - 416
SICI:
0263-6352(1993)11:4<407:CIOE2I>2.0.ZU;2-C
Fonte:
ISI
Lingua:
ENG
Soggetto:
BLOOD-PRESSURE; NEUTRAL METALLOENDOPEPTIDASE; ADRENAL GLOMERULOSA; ARTERIAL-PRESSURE; CHRONIC INFUSION; CONSCIOUS SHR; RESPONSES; SODIUM; PLASMA; RADIOIMMUNOASSAY;
Keywords:
CYCLIC GUANOSINE MONOPHOSPHATE; RENIN ANGIOTENSIN ALDOSTERONE SYSTEM; CATECHOLAMINES; NATRIURESIS; BLOOD PRESSURE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
40
Recensione:
Indirizzi per estratti:
Citazione:
A.M. Richards et al., "CHRONIC INHIBITION OF ENDOPEPTIDASE 24.11 IN ESSENTIAL-HYPERTENSION -EVIDENCE FOR ENHANCED ATRIAL-NATRIURETIC-PEPTIDE AND ANGIOTENSIN-II", Journal of hypertension, 11(4), 1993, pp. 407-416

Abstract

Aim: To determine the renal, endocrine and haemodynamic effects of anorally active inhibitor of the neutral endopeptidase EC 3.4.24.11 in essential hypertension. Methods:Two groups of 12 white male patients with essential hypertension were treated with candoxatril at 25 mg every 12 h (group 1) or at 200 mg every 12 h (group 2) for 5 days in double-blind, placebo-controlled, crossover studies. Results: Candoxatril enhanced natriuresis over the initial 48 h of treatment. Twenty-four-hour diurnal hormone profiles (day 4) showed modest elevations in plasmaatrial natriuretic factor (ANF) concentrations and more clear-cut increases in plasma and urinary cyclic GMP. Plasma angiotensin 11 and aldosterone concentrations were also significantly increased. Plasma catecholamine concentrations were significantly increased by the higher dose of candoxatril. Blood pressure (day 4, 24-h intra-arterial recordings) fell significantly with both doses. The infusions of exogenous ANFand angiotensin 11 on day 5 showed that candoxatril impaired the metabolic clearance of both ANF and angiotensin II with consequent enhancement of the biological effects of both effector peptides. Conclusions:Candoxatril augments the effects of ANF and lowers blood pressure in patients with hypertension. However, the antihypertensive effects may be offset by increased angiotensin-aldosterone and sympathetic nervoussystem activity. The blood pressure response to endopeptidase inhibition in hypertensive patients may depend on the relative effects on humoral vasodilator (including ANF) and vasoconstrictor (including the angiotensin-aldosterone and sympathetic) systems.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 11/07/20 alle ore 11:16:14