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Titolo:
ENDOTHELIN-1 RECEPTORS ON THE HUMAN PLACENTA AND FETAL MEMBRANES - EVIDENCE FOR DIFFERENT BINDING-PROPERTIES IN PREECLAMPTIC PREGNANCIES
Autore:
SCHIFF E; GALRON R; BENBARUCH G; MASHIACH S; SOKOLOVSKY M;
Indirizzi:
TEL AVIV UNIV,SACKLER SCH MED,SHEBA MED CTR,DEPT OBSTET IL-52621 TEL HASHOMER ISRAEL
Titolo Testata:
Gynecological endocrinology
fascicolo: 1, volume: 7, anno: 1993,
pagine: 67 - 72
SICI:
0951-3590(1993)7:1<67:EROTHP>2.0.ZU;2-#
Fonte:
ISI
Lingua:
ENG
Keywords:
ENDOTHELIN-1; PREECLAMPSIA; PREGNANCY-INDUCED HYPERTENSION; BINDING ASSAY;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
NO
Recensione:
Indirizzi per estratti:
Citazione:
E. Schiff et al., "ENDOTHELIN-1 RECEPTORS ON THE HUMAN PLACENTA AND FETAL MEMBRANES - EVIDENCE FOR DIFFERENT BINDING-PROPERTIES IN PREECLAMPTIC PREGNANCIES", Gynecological endocrinology, 7(1), 1993, pp. 67-72

Abstract

Densities and affinities of tissue protein receptor sites for endothelin-1 in placental and fetal membranes of six pre-eclamptic and 16 normotensive women in the 36-41th week of gestation were determined by the use of a binding assay with [I-125]endothelin-1. The mean maximal density of receptor sites (B(max)) was significantly higher in the placentas of the pre-eclamptic than of the normotensive women (905 +/- 107 vs. 539 +/- 140 fmol/mg protein, p < 0.0001). No differences uere found between the two groups with respect to the mean affinity (K(d)) of placental receptors, or the mean B(max) and the mean K(d) of fetal chorionic samples. In the normotensive group, there uere no differences inmean placental B(max) values or in mean K(d) values between women whowent into spontaneous labor (whether delivered vaginally or abdominally) and those who uere electively operated on prior to labor onset. Nobinding sites uere detected in the fetal amniotic membranes of any ofthe women. Our results suggest that an increase in the maximal density of receptor sites to endothelin-1 in the placenta may play a role inthe pathophysiology of pre-eclampsia by contributing to the placentalinsufficiency that characterizes this disorder.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 02/12/20 alle ore 18:35:51