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Titolo:
STIMULATION OF INSULIN-SECRETION AND IMPROVEMENT OF GLUCOSE-TOLERANCEIN RAT AND DOG BY THE P2Y-PURINOCEPTOR AGONIST, ADENOSINE-5'-O-(2-THIODIPHOSPHATE)
Autore:
HILLAIREBUYS D; BERTRAND G; CHAPAL J; PUECH R; RIBES G; LOUBATIERESMARIANI MM;
Indirizzi:
FAC MED MONTPELLIER,INST BIOL,PHARMACOL LAB,CNRS,URA 599,BLVD HENRI IV F-34060 MONTPELLIER FRANCE
Titolo Testata:
British Journal of Pharmacology
fascicolo: 1, volume: 109, anno: 1993,
pagine: 183 - 187
SICI:
0007-1188(1993)109:1<183:SOIAIO>2.0.ZU;2-1
Fonte:
ISI
Lingua:
ENG
Soggetto:
PANCREAS; ANALOGS;
Keywords:
P2Y-PURINOCEPTORS; ADENOSINE-5'-O-(2-THIODIPHOSPHATE) (ADP-BETA-S); INSULIN SECRETION; GLUCOSE TOLERANCE IN RAT, IN DOG;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
13
Recensione:
Indirizzi per estratti:
Citazione:
D. Hillairebuys et al., "STIMULATION OF INSULIN-SECRETION AND IMPROVEMENT OF GLUCOSE-TOLERANCEIN RAT AND DOG BY THE P2Y-PURINOCEPTOR AGONIST, ADENOSINE-5'-O-(2-THIODIPHOSPHATE)", British Journal of Pharmacology, 109(1), 1993, pp. 183-187

Abstract

1 In vivo effect of a P2y-purinoceptor agonist, adenosine-5'-O-(2-thiodiphosphate) (ADPbetaS), on insulin secretion and glycaemia were studied both in rats and dogs. 2 In anaesthetized rats, i.v. administered ADPbetaS (0.2 mg kg-1) produced an insulin response dependent on the nutritional state of the animals, since we observed only a transient increase in overnight-fasted rats and a sustained insulin secretion followed by a reduction in plasma glucose levels in fed rats. During an i.v. glucose tolerance test, ADPbetaS enhanced insulin release and thus increased the glucose disappearance rate. 3 In anaesthetized fasted dogs, i.v. administered ADPbetaS (0.1 mg kg-1) increased pancreaticoduodenal insulin output and slightly decreased blood glucose levels. 4 In conscious fasted dogs, orally administered ADPbetaS (0.1 mg kg-1) transiently increased insulinemia and punctually reduced glycaemia. Furthermore, during an oral glucose tolerance test, orally administered ADPbetaS at the same dose markedly enhanced insulin secretion and consequently reduced the hyperglycaemia. 5 In conclusion, the P2y-agonist, ADPbetaS, is a potent insulin secretagogue in vivo, improves glucose tolerance and is effective after oral administration. Thus, the P2y-purinoceptors of the beta cell may be a target for new antidiabetic drugs.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 13/08/20 alle ore 14:10:29