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Titolo:
IMPORTANCE OF HYPOTHALAMIC FUNCTION TO STRESSOR-INDUCED RESPONSIVENESS OF THE GABA-A RECEPTOR IN THE CEREBRAL-CORTEX - A NON-CORTICOSTERONEINFLUENCE
Autore:
KELLOGG CK; INGLEFIELD JR; TAYLOR MK; PLEGER GL;
Indirizzi:
UNIV ROCHESTER,DEPT PSYCHOL,ROOM 186,MELIORA HALL ROCHESTER NY 14627 UNIV ROCHESTER,DEPT NEUROBIOL & ANAT ROCHESTER NY 14627
Titolo Testata:
Brain research
fascicolo: 1-2, volume: 609, anno: 1993,
pagine: 244 - 252
SICI:
0006-8993(1993)609:1-2<244:IOHFTS>2.0.ZU;2-1
Fonte:
ISI
Lingua:
ENG
Soggetto:
CHLORIDE-ION CHANNEL; BENZODIAZEPINE RECEPTORS; PARAVENTRICULAR NUCLEUS; EXPERIMENTAL ANXIETY; RAT-BRAIN; NEURONS; BINDING; COMPLEX; SYSTEM; NOREPINEPHRINE;
Keywords:
6-HYDROXYDOPAMINE; PARAVENTRICULAR NUCLEUS; CATECHOLAMINE; SOCIAL INTERACTION TEST; STRESS; CORTICOSTERONE; ALLOTETRAHYDRODEOXYCORTICOSTERONE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
48
Recensione:
Indirizzi per estratti:
Citazione:
C.K. Kellogg et al., "IMPORTANCE OF HYPOTHALAMIC FUNCTION TO STRESSOR-INDUCED RESPONSIVENESS OF THE GABA-A RECEPTOR IN THE CEREBRAL-CORTEX - A NON-CORTICOSTERONEINFLUENCE", Brain research, 609(1-2), 1993, pp. 244-252

Abstract

Catecholamine terminals in the paraventricular nucleus (PVN) of the hypothalamus of 60-day-old rats were destroyed by the stereotaxic injection of 6-hydroxydopamine into the PVN (6-OHDA; 9 mug/1.5 mul bilaterally), and the rats were tested 2 weeks later. Lesions led to a 70% reduction of norepinephrine in the hypothalamus and a loss of dopamine-beta-hydroxylase immunoreactivity in the PVN. Furthermore, 6-OHDA lesions in the hypothalamus disrupted stressor-induced (15 min of restraint)changes in GABA(A) receptor function in the cerebral cortex (assessedby measuring chloride-facilitated benzodiazepine binding) but did notalter stressor-induced increases in plasma corticosterone levels. Additionally, the lesion did not change the responsiveness of the GABA(A)receptor to the corticosterone metabolite, allotetrahydrodeoxycorticosterone. These results indicate that stressor-induced changes in cortical GABA(A) receptor function are not driven by the stressor-induced release of corticosterone. A separate group of animals were tested for behavioral responses to challenge, and while 6-OHDA-induced lesions did not alter total scores in the test of environment-specific social interaction, the lesions did induce a change in composition of the behavior. Lesioned animals demonstrated increased physical (vigorous contact) interactions, similar to behavior previously observed in younger rats. The results of the behavioral study support a role for the GABA(A)receptor in the cerebral cortex in mediating appropriate behavioral responses to challenge in the adult rat. Thus, a hypothalamic lesion that prevented challenge-induced changes in GABA(A) receptor function inthe cortex (with no change in the corticosterone response to the stressor) also led to altered behavioral responses to challenge.

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Documento generato il 26/05/20 alle ore 04:36:21