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Titolo:
IDENTIFICATION OF EXTRASTRIATAL DOPAMINE D2 RECEPTORS IN POSTMORTEM HUMAN BRAIN WITH [I-125] EPIDEPRIDE
Autore:
KESSLER RM; WHETSELL WO; ANSARI MS; VOTAW JR; DEPAULIS T; CLANTON JA; SCHMIDT DE; MASON NS; MANNING RG;
Indirizzi:
VANDERBILT UNIV,MED CTR,SCH MED,DEPT RADIOL,2222 PIERCE AVE,MRB 1251 NASHVILLE TN 37232 VANDERBILT UNIV,MED CTR,SCH MED,DEPT PSYCHIAT NASHVILLE TN 37232
Titolo Testata:
Brain research
fascicolo: 1-2, volume: 609, anno: 1993,
pagine: 237 - 243
SICI:
0006-8993(1993)609:1-2<237:IOEDDR>2.0.ZU;2-T
Fonte:
ISI
Lingua:
ENG
Soggetto:
HIGH-AFFINITY; AUTORADIOGRAPHIC LOCALIZATION; ATYPICAL NEUROLEPTICS; I-125 EPIDEPRIDE; INVITRO BINDING; H-3 RACLOPRIDE; BASAL GANGLIA; RAT-BRAIN; CORTEX; SCHIZOPHRENIA;
Keywords:
DOPAMINE D2 RECEPTOR; LIMBIC D2 RECEPTOR; THALAMIC D2 RECEPTOR; CORTICAL D2 RECEPTOR; (I-125)EPIDEPRIDE; EXTRASTRIATAL D2 RECEPTOR; HUMAN BRAIN POSTMORTEM STUDY;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
36
Recensione:
Indirizzi per estratti:
Citazione:
R.M. Kessler et al., "IDENTIFICATION OF EXTRASTRIATAL DOPAMINE D2 RECEPTORS IN POSTMORTEM HUMAN BRAIN WITH [I-125] EPIDEPRIDE", Brain research, 609(1-2), 1993, pp. 237-243

Abstract

The regional distribution of striatal and extrastriatal dopamine D2 receptors in human brain was studied in vitro with inyl)methyl]-5-[I-125]iodo-2,3-dimethoxybenzamide, [I-125]epidepride, using Post mortem brain specimens from six subjects. Scatchard analysis of the saturation equilibrium binding in twenty-three regions of post mortem brain revealed highest levels of binding in the caudate (16.5 pmol/g tissue) and putamen (16.6 pmol/g tissue) with lower levels seen in the globus pallidus (7.0 pmol/g tissue), nucleus accumbens (7.2 pmol/g tissue), hypothalamus (1.8 pmol/g tissue), pituitary (1.3 pmol/g tissue), substantiainnominata (1.0 pmol/g tissue), and amygdala (0.87 pmol/g tissue). Ofnote was the presence of dopamine D2 receptors in the four thalamic nuclei studied, i.e. anterior nucleus (1.0 pmol/g tissue), dorsomedial nucleus (0.96 pmol/g tissue), ventral nuclei (0.72 pmol/g tissue), andpulvinar (0.86 pmol/g tissue), at levels comparable to the amygdala (0.87 pmol/g tissue) and considerably higher than levels seen in anterior cingulate (0.26 pmol/g tissue) or anterior hippocampus (0.36 pmol/gtissue). The frontal cortex had very low levels of dopamine D2 receptors (0.17-0.20 pmol/g tissue) while the inferior and medial temporal cortex had relatively higher levels (0.31-0.46 pmol/g tissue). Inhibition of [I-125]epidepride binding by a variety of neurotransmitter ligands to striatal, ventral thalamic and inferior temporal cortical homogenates demonstrated that [I-125]epidepride binding was potently inhibited only by dopamine D2 ligands. The present study demonstrates that dopamine D2 receptors are present in basal ganglia, many limbic regions,cortex and in the thalamus. The density of thalamic D2 receptors is comparable to many limbic regions and is considerably higher than in cor-tex. Very few frontal lobe D2 receptors are present in man.

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Documento generato il 12/12/19 alle ore 15:05:56