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Titolo:
ALTERATIONS IN GLUCOCORTICOID INDUCIBLE RNAS IN THE LIMBIC SYSTEM OF LEARNED HELPLESS RATS
Autore:
LACHMAN HM; PAPOLOS DF; BOYLE A; SHEFTEL G; JUTHANI M; EDWARDS E; HENN FA;
Indirizzi:
YESHIVA UNIV ALBERT EINSTEIN COLL MED,DEPT MED,DEPT PSYCHIAT,PROGRAM BEHAV GENET BRONX NY 10461 SUNY STONY BROOK,DEPT PSYCHIAT STONY BROOK NY 11794 UNIV MARYLAND,DEPT PHARMACOL & TOXIKOL BALTIMORE MD 21201
Titolo Testata:
Brain research
fascicolo: 1-2, volume: 609, anno: 1993,
pagine: 110 - 116
SICI:
0006-8993(1993)609:1-2<110:AIGIRI>2.0.ZU;2-S
Fonte:
ISI
Lingua:
ENG
Soggetto:
RECEPTOR MESSENGER-RNA; RIBONUCLEIC-ACID; ANIMAL-MODEL; DIFFERENTIAL REGULATION; INSITU HYBRIDIZATION; NEGATIVE REGULATION; DOWN-REGULATION; C-JUN; BRAIN; DEPRESSION;
Keywords:
GLUCOCORTICOID; GLUCOCORTICOID RECEPTOR; GENE EXPRESSION; HIPPOCAMPUS; HYPOTHALAMUS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
53
Recensione:
Indirizzi per estratti:
Citazione:
H.M. Lachman et al., "ALTERATIONS IN GLUCOCORTICOID INDUCIBLE RNAS IN THE LIMBIC SYSTEM OF LEARNED HELPLESS RATS", Brain research, 609(1-2), 1993, pp. 110-116

Abstract

Glucocorticoids (GC) have an important effect on mood in humans and influence learned helplessness, an escape avoidance paradigm that is considered one of the best animal models of depression. A strong geneticcomponent underlies the development of learned helplessness as shown by the emergence of a line of highly vulnerable rats (LH strain) through selective inbreeding. In addition, hormonal factors play a role. Adrenalectomy (adx) for example is known to increase the vulnerability to acquire learned helplessness, an effect that is reversed by glucocorticoids (GC). Since GC function primarily by modulating gene expression, hormone mediated alterations in mRNAs expressed in the brain may beimportant in the development of an adequate escape avoidance response. Conversely, we postulate that the deficit in escape avoidance behavior exhibited by the LH strain may be associated with an alteration in GC-mediated gene expression in the brain. To test this hypothesis, we analyzed GC-responsive mRNAs that are expressed in the hippocampus. Control Sprague-Dawley (SD) rats showed consistent alterations in mRNAs that are modulated by GC, such as type II GC receptor (GR) and metallothionein-1 (MT-1). Under our experimental conditions, both GR and MT-1mRNA are significantly increased in the hippocampus of hormone-treated SD rats. An increase in hypothalamic GR mRNA was also observed. However, under the same experimental conditions, LH rats showed more selective hormone induced changes since GC had no effect on hypothalamic and hippocampal GR mRNA whereas a significant increase in MT-1 mRNA was observed. The data support the hypothesis that the increased vulnerability exhibited by LH rats is correlated with alterations in GC-mediated gene expression in limbic structures.

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Documento generato il 08/07/20 alle ore 07:59:13