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Titolo:
EXOGENOUS SURFACTANT THERAPY INCREASES STATIC LUNG COMPLIANCE, AND CANNOT BE ASSESSED BY MEASUREMENTS OF DYNAMIC COMPLIANCE ALONE
Autore:
GOMMERS D; VILSTRUP C; BOS JAH; LARSSON A; WERNER O; HANNAPPEL E; LACHMANN B;
Indirizzi:
ERASMUS UNIV,DEPT ANESTHESIOL,ROOM EE 2393,POB 1738 3000 DR ROTTERDAMNETHERLANDS ERASMUS UNIV,DEPT ANESTHESIOL,ROOM EE 2393,POB 1738 3000 DR ROTTERDAMNETHERLANDS UNIV LUND,DEPT ANESTHESIOL S-22101 LUND SWEDEN UNIV ERLANGEN NURNBERG,DEPT BIOCHEM W-8520 ERLANGEN GERMANY
Titolo Testata:
Critical care medicine
fascicolo: 4, volume: 21, anno: 1993,
pagine: 567 - 574
SICI:
0090-3493(1993)21:4<567:ESTISL>2.0.ZU;2-O
Fonte:
ISI
Lingua:
ENG
Soggetto:
RESPIRATORY-DISTRESS SYNDROME; HIGH-FREQUENCY VENTILATION; END-EXPIRATORY PRESSURE; MECHANICAL VENTILATION; OXYGENATION; INFANTS; RABBITS; VOLUME;
Keywords:
RESPIRATORY DISTRESS SYNDROME; PULMONARY SURFACTANTS; LUNG VOLUME MEASUREMENTS; LUNG COMPLIANCE; LUNG; DISEASE MODELS, ANIMAL; PULMONARY GAS EXCHANGE; FUNCTIONAL RESIDUAL CAPACITY; RESPIRATORY MECHANICS; CRITICAL ILLNESS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
24
Recensione:
Indirizzi per estratti:
Citazione:
D. Gommers et al., "EXOGENOUS SURFACTANT THERAPY INCREASES STATIC LUNG COMPLIANCE, AND CANNOT BE ASSESSED BY MEASUREMENTS OF DYNAMIC COMPLIANCE ALONE", Critical care medicine, 21(4), 1993, pp. 567-574

Abstract

Objective: To study the immediate effects of exogenous surfactant therapy on blood gases, lung volumes, and lung mechanics in adult rabbitswith experimentally induced respiratory distress syndrome. Design. Prospective randomized, controlled study. Setting. Laboratory and animalfacility of a large university. Subjects. Twelve adult New Zealand white rabbits. Interventions. Respiratory failure was induced by repeated bilateral whole-lung lavage with saline (30 mL/kg body weight). After the last lavage, the animals were randomly assigned to two groups. Group 1 received surfactant (120 mg/kg body weight) that was suspended in a 0.6% sodium chloride solution. Group 2 received comparable volumes of the same hypotonic solution and served as controls. Measurements and Main Results: Before and after endotracheal surfactant instillation, blood gases and functional residual capacity were measured, and lung mechanics from tidal volumes and pressure-volume curves were calculated. Functional residual capacity was measured by a computerized, multiple-breath, washin-washout method using sulfur hexafluoride (SF6) as tracer gas. The pressure-volume curves were obtained by an occlusion technique originally described for measuring static breath-by-breath compliance. The technique was modified for present use and fully computerized. Within 60 mins after surfactant instillation, there were markedimprovements in Pao2 (61 +/- torr [8.2 +/- 0.9 kPa] to 470 +/- 47 torr [62.6 +/- 6.2 kPa]) and in functional residual capacity (7.6 +/- 1.4to 17.7 +/- 1.6 mL/kg body weight) at unchanged ventilatory settings. The pressure-volume curves became steeper over time and the pressure-volume curves for total lung volume were restored to an almost normal state. Maximum compliance calculated from the pressure-volume curves increased by 92% but there was no significant change in dynamic compliance. In the control group, no improvements in any measured or calculated lung parameters were seen. Conclusions. The findings indicate that during mechanical ventilation, the effects of surfactant therapy on lung mechanics are best characterized by changes in functional residual capacity and maximum compliance obtained from static pressure-volume curves and not by dynamic compliance.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 07/08/20 alle ore 06:47:40