Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
ESTROGEN PRODUCTIVITY OF ENDOMETRIUM AND ENDOMETRIAL CANCER-TISSUE - INFLUENCE OF AROMATASE ON PROLIFERATION OF ENDOMETRIAL CANCER-CELLS
Autore:
YAMAMOTO T; KITAWAKI J; URABE M; HONJO H; TAMURA T; NOGUCHI T; OKADA H; SASAKI H; TADA A; TERASHIMA Y; NAKAMURA J; YOSHIHAMA M;
Indirizzi:
KYOTO PREFECTURAL UNIV MED,DEPT OBSTET & GYNECOL,KAMIKYO KU KYOTO 602JAPAN JIKEI UNIV SCH MED,DEPT OBSTET & GYNECOL,MINATO KU TOKYO 105 JAPAN SNOW BRAND MILK PROD CO,LIFE SCI RES INST TOCHIGI 32905 JAPAN
Titolo Testata:
Journal of steroid biochemistry and molecular biology
fascicolo: 4-6, volume: 44, anno: 1993,
pagine: 463 - 468
SICI:
0960-0760(1993)44:4-6<463:EPOEAE>2.0.ZU;2-2
Fonte:
ISI
Lingua:
ENG
Soggetto:
ANDROSTENEDIONE; SULFATASE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
9
Recensione:
Indirizzi per estratti:
Citazione:
T. Yamamoto et al., "ESTROGEN PRODUCTIVITY OF ENDOMETRIUM AND ENDOMETRIAL CANCER-TISSUE - INFLUENCE OF AROMATASE ON PROLIFERATION OF ENDOMETRIAL CANCER-CELLS", Journal of steroid biochemistry and molecular biology, 44(4-6), 1993, pp. 463-468

Abstract

Aromatase, estrone (E1) sulfatase and E1 sulfotransferase activities were examined in endometrium and endometrial cancer tissue preparations. Aromatase and E1 sulfatase activities in endometrial cancer tissueswere found to be significantly higher than in normal endometrial tissues. However, E1 sulfotransferase activity did not differ between benign and malignant tissue. We also examined the effect of testosterone (T) on aromatase activity and tritiated thymidine uptake (DNA synthesis) in various cultured cervical or corpus endometrial cancer cell lines(OMC-4, HHUA, Ishikawa, HEC-59). The results demonstrated that only the HEC-59 cell line had high aromatase activity and increased its DNA synthesis in response to T. This increase of DNA synthesis by T was not suppressed by simultaneous addition of cyproterone acetate, but was by tamoxifen. These data suggest that in situ estrogen production in endometrial cancer tissue is biologically important and that aromatase in cancer cells may contribute partially to cell proliferation if androgen substrate is provided.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 25/11/20 alle ore 18:38:38