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Titolo:
PERINDOPRIL AS MONOTHERAPY IN HYPERTENSION - A MULTICENTER COMPARISONOF 2 DOSING REGIMENS
Autore:
CHRYSANT SG; MCDONALD RH; WRIGHT JT; BARDEN PL; WEISS RJ;
Indirizzi:
UNIV OKLAHOMA HLTH SCI CTR,OKLAHOMA CARDIOVASC & HYPERTENS CTR,5850 WWILSHIRE BLVD OKLAHOMA CITY OK 73132 UNIV PITTSBURGH,SCH MED PITTSBURGH PA 15261 CASE WESTERN RESERVE UNIV,DIV ENDOCRINOL & HYPERTENS CLEVELAND OH 44106 LANE RES ALBUQUERQUE NM 00000 ST MARYS REG MED CTR LEWISTON ME 00000
Titolo Testata:
Clinical pharmacology and therapeutics
fascicolo: 4, volume: 53, anno: 1993,
pagine: 479 - 484
SICI:
0009-9236(1993)53:4<479:PAMIH->2.0.ZU;2-6
Fonte:
ISI
Lingua:
ENG
Soggetto:
CONVERTING-ENZYME-INHIBITOR; HEART-FAILURE; ENALAPRIL; CAPTOPRIL; LISINOPRIL;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
28
Recensione:
Indirizzi per estratti:
Citazione:
S.G. Chrysant et al., "PERINDOPRIL AS MONOTHERAPY IN HYPERTENSION - A MULTICENTER COMPARISONOF 2 DOSING REGIMENS", Clinical pharmacology and therapeutics, 53(4), 1993, pp. 479-484

Abstract

Perindopril erbumine, a new long-acting, non-sulfhydryl-containing angiotensin converting enzyme inhibitor, was evaluated in 289 patients with hypertension in a 16-week, double-blind, placebo-controlled dose-ranging study. After 4 weeks of single-blind placebo treatment, patients with supine diastolic arterial pressures from 95 to 114 mm Hg were randomized to receive placebo, 4 mg perindopril once daily, or 2 mg perindopril twice daily. The daily dose of perindopril was increased by 4mg every 4 weeks to a maximum of 16 mg per day. Mean decreases in systolic and diastolic arterial pressure were greater with perindopril than with placebo (p < 0.05). The dose-response curve flattened after 8 mg per day, and there was no difference in arterial pressure reductionor in the percentage of responders between once- and twice-daily administration of perindopril. Adverse reactions with perindopril were generally mild and, with the exception of cough, were similar with placebo. The findings of this study indicate that perindopril is effective, well tolerated, and suitable for once-daily administration for the treatment of hypertension.

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Documento generato il 25/11/20 alle ore 06:28:42