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Titolo:
LOW EDUCATION AS A POSSIBLE RISK FACTOR FOR COGNITIVE ABNORMALITIES IN HIV-1 - FINDINGS FROM THE MULTICENTER AIDS COHORT STUDY (MACS)
Autore:
SATZ P; MORGENSTERN H; MILLER EN; SELNES OA; MCARTHUR JC; COHEN BA; WESCH J; BECKER JT; JACOBSON L; DELIA LF; VANGORP W; VISSCHER B;
Indirizzi:
UCLA,INST NEUROPSYCHIAT,ROOM C8-747 NPI,760 WESTWOOD PLAZA LOS ANGELES CA 90024 UCLA,SCH PUBL HLTH LOS ANGELES CA 00000 JOHNS HOPKINS MED INST BALTIMORE MD 21205 NORTHWESTERN UNIV,SCH MED CHICAGO IL 60611 HOWARD BROWN MEM CLIN CHICAGO IL 00000 UNIV PITTSBURGH PITTSBURGH PA 15260
Titolo Testata:
Journal of acquired immune deficiency syndromes
fascicolo: 5, volume: 6, anno: 1993,
pagine: 503 - 511
SICI:
0894-9255(1993)6:5<503:LEAAPR>2.0.ZU;2-J
Fonte:
ISI
Lingua:
ENG
Soggetto:
HUMAN-IMMUNODEFICIENCY-VIRUS; NEUROPSYCHOLOGICAL FINDINGS; NEUROLOGIC ABNORMALITIES; CEREBROSPINAL-FLUID; DEMENTIA COMPLEX; HOMOSEXUAL MEN; NERVOUS-SYSTEM; HTLV-III; INFECTION; MANIFESTATIONS;
Keywords:
HIV; ASYMPTOMATIC SUBJECTS; EDUCATION; RISK FACTORS; NEUROPSYCHOLOGY;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
39
Recensione:
Indirizzi per estratti:
Citazione:
P. Satz et al., "LOW EDUCATION AS A POSSIBLE RISK FACTOR FOR COGNITIVE ABNORMALITIES IN HIV-1 - FINDINGS FROM THE MULTICENTER AIDS COHORT STUDY (MACS)", Journal of acquired immune deficiency syndromes, 6(5), 1993, pp. 503-511

Abstract

The present study reports new and unexpected results of cognitive abnormalities among human immunodeficiency virus type 1 (HIV-1) asymptomatic subjects in the Multicenter AIDS Cohort Study. The major purpose of our analyses is to estimate the separate and combined effects of serostatus and education level on the prevalence of cognitive abnormality. Cognitive ''abnormality'' was defined as performance that deviated greater-than-or-equal-to 2 SDs below the mean of the total seronegativegroup on at least one of the five neuropsychological screening tests (Grooved Pegboard, Verbal Fluency, Digit Span, Symbol Digit Modalities, Rey Auditory Verbal Learning). The predicted prevalence of cognitiveabnormality was 38% in seropositive individuals with no more than 12 years of education, compared with <17% in the other education-serostatus groups. This interaction between education level and serostatus remained after controlling for the possible confounding effects of age, ethnicity, CD4 level, depression, prior drug history, and learning disability using logistic regression. To account for these findings, we suggest that low education might reflect an indirect index of lower reserve capacity (i.e., a risk factor) that lowers the threshold for neuropsychological abnormalities in cases of early HIV-1 infection.

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Documento generato il 30/11/20 alle ore 02:59:48